Transport of nucleotide sugars

Stable Identifier
R-HSA-727802
Type
Pathway
Species
Homo sapiens
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Nucleotide sugars are used as sugar donors by glycosyltransferases to create the sugar chains for glycoconjugates such as glycoproteins, polysaccharides and glycolipids. Glycosyltransferases reside mainly in the lumen of the Golgi apparatus and endoplasmic reticulum (ER) whereas nucleotide sugars are synthesized in the cytosol. The human solute carrier family SLC35 encode nucleotide sugar transporters (NSTs) which can mediate the antiport of nucleotide sugars in exchange for the corresponding nucleoside monophosphates (eg. UMP for UDP-sugars). Owing to their function, NSTs are primarily located on Golgi and ER membranes (He L et al, 2009; Handford M et al, 2006; Ishida N and Kawakita M, 2004).

Literature References
PubMed ID Title Journal Year
19164095 Analysis and update of the human solute carrier (SLC) gene superfamily

He, L, Vasiliou, K, Nebert, DW

Hum Genomics 2009
16981043 Nucleotide-sugar transporters: structure, function and roles in vivo

Handford, M, Rodriguez-Furlán, C, Orellana, A

Braz J Med Biol Res 2006
12759756 Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35)

Ishida, N, Kawakita, M

Pflugers Arch 2004
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