SLC35A1 exchanges CMP-Neu5Ac for CMP

Stable Identifier
R-HSA-727807
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SLC35A1 mediates the antiport of CMP-sialic acid in exchange for CMP
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human gene SLC35A1 encodes the CMP-sialic acid transporter which mediates the antiport of CMP-sialic acid (CMP-Neu5Ac) into the Golgi lumen in exchange for CMP (Ishida et al. 1996). Defects in SLC35A1 are the cause of congenital disorder of glycosylation type 2F (CDG2F; MIM:603585). CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation (Martinez-Duncker et al. 2005).

Literature References
PubMed ID Title Journal Year
9010752 Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family

Ishida, N, Miura, N, Yoshioka, S, Kawakita, M

J Biochem 1996
15576474 Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter

Martinez-Duncker, I, Dupré, T, Piller, V, Piller, F, Candelier, JJ, Trichet, C, Tchernia, G, Oriol, R, Mollicone, R

Blood 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
CMP-N-acetylneuraminate transmembrane transporter activity of SLC35A1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created