Reactome | TK1 [cytosol]

TK1 [cytosol]

Stable Identifier

R-HSA-73500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

thymidine kinase 1, soluble, Thymidine kinase, cytosolic (EC 2.7.1.21), Thymidine kinase, cytosolic

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04183 TK1

Gene Names

TK1, TK, Thymidine kinase

Chain

initiator methionine:, chain:2-234

Reference Genes

BioGPS Gene:7083 TK1

COSMIC (genes):TK1 TK1

CTD Gene:7083 TK1

dbSNP Gene:7083 TK1

ENSEMBL:ENSG00000167900 TK1

HGNC:11830 TK1

KEGG:hsa:7083 TK1

Monarch:7083 TK1

NCBI Gene:7083 TK1

OMIM:188300 TK1

UCSC:P04183 TK1

Reference Transcript

RefSeq:NM_003258.4 TK1

Other Identifiers

11718127_at

11718128_x_at

1554408_PM_a_at

1554408_a_at

16849379

202338_PM_at

202338_at

3772159

3772160

3772161

3772162

3772163

3772164

3772165

3772166

3772167

3772168

3772169

3772170

3772171

3772172

3772173

3772174

41400_at

7083

8018849

910_at

A_23_P107421

A_24_P915535

GE57538

GO:0003824

GO:0004797

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006139

GO:0008270

GO:0009157

GO:0016301

GO:0016740

GO:0042802

GO:0043226

GO:0046104

GO:0046105

GO:0046872

GO:0051289

GO:0055086

GO:0065003

GO:0071897

GO:1901135

GO:1904860

HMNXSV003009883

Hs2.105097.2.S1_3p_s_at

ILMN_1806037

M15205_at

PH_hs_0022775

PH_hs_0035630

TC17001914.hg

g4507518_3p_at

g4507518_3p_x_at

Participates

as an output of

TK1 gene expression is stimulated by E2F1 (Homo sapiens)

as a component of

TK1 tetramer [cytosol] (Homo sapiens)

Inferred To

thk-1 [cytosol] (Caenorhabditis elegans)

tk1 [cytosol] (Xenopus tropicalis)

AC112350.1 [cytosol] (Rattus norvegicus)

TK1 [cytosol] (Bos taurus)

TK1 [cytosol] (Canis familiaris)

TK1 [cytosol] (Danio rerio)

TK1 [cytosol] (Dictyostelium discoideum)

TK1 [cytosol] (Gallus gallus)

TK1 [cytosol] (Mus musculus)

TK1 [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000167900

ENSEMBL

ENSP00000301634, ENST00000301634

HPA

ENSG00000167900-TK1

ZINC target

P04183

PRO

P04183

Pharos - Targets

P04183

GlyGen

P04183

PDB

2WVJ, 1W4R, 2ORV, 1XBT

HMDB Protein

HMDBP03814

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.592	2
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q1RN33 Q1RN33			0.556	3
UniProt:A0A087WZT3 A0A087WZT3			0.556	3
UniProt:Q15262 PTPRK	1	PTPRK [plasma membrane] (R-HSA-6785699)	0.553	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.553	2
UniProt:Q13885 TUBB2A	6	TUBB2A folding intermediate [cytosol] (R-HSA-392802) TUBB2A unfolded [cytosol] (R-HSA-392776) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699)	0.553	2
UniProt:Q9UKR5 ERG28			0.553	2
UniProt:O60383 GDF9			0.553	2
UniProt:Q5RL73 RBM48			0.553	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:P51693 APLP1			0.553	2
UniProt:Q13432 U119A			0.553	2
UniProt:Q9GZT6 CC90B			0.553	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.553	2
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.553	2
UniProt:Q04724 TLE1	2	Ub-TLE1 [nucleoplasm] (R-HSA-3322369) TLE1 [nucleoplasm] (R-HSA-212327)	0.553	2
UniProt:Q14194 CRMP1	4	p-T509,T514,S518,S522-CRMP1 [cytosol] (R-HSA-399777) p-S522-CRMP1 [cytosol] (R-HSA-399779) p-Y-CRMP1 [cytosol] (R-HSA-399784) CRMP1 [cytosol] (R-HSA-398120)	0.553	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.547	2
UniProt:O00253 AGRP	1	AGRP [nucleoplasm] (R-HSA-9623016)	0.527	2
UniProt:P50238 CRIP1			0.527	2
UniProt:P62166 NCS1			0.527	2

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