Reactome | TK1 [cytosol]

TK1 [cytosol]

Stable Identifier

R-HSA-73500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

thymidine kinase 1, soluble, Thymidine kinase, cytosolic (EC 2.7.1.21), Thymidine kinase, cytosolic

Locations in the PathwayBrowser for interactor UniProt:Q7L5N1 COPS6

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External Reference Information

External Reference

UniProt:P04183 TK1

Gene Names

TK1

Chain

initiator methionine:1, chain:2-234

Reference Genes

BioGPS Gene:7083 TK1

COSMIC (genes):TK1 TK1

CTD Gene:7083 TK1

dbSNP Gene:7083 TK1

ENSEMBL:ENSG00000167900 TK1

HGNC:11830 TK1

KEGG Gene (Homo sapiens):7083 TK1

Monarch:7083 TK1

NCBI Gene:7083 TK1

OMIM:188300 TK1

UCSC:P04183 TK1

Reference Transcript

RefSeq:NM_003258.4 TK1

Other Identifiers

0004120180

11718127_at

11718128_x_at

1554408_a_at

16849379

202338_at

3772159

3772160

3772161

3772162

3772163

3772165

3772166

3772167

3772168

3772169

3772170

3772172

3772173

41400_at

7083

8018849

910_at

A_23_P107421

A_24_P915535

GE57538

GO:0000166

GO:0003674

GO:0004797

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006139

GO:0006259

GO:0008150

GO:0008270

GO:0009058

GO:0009157

GO:0016301

GO:0016310

GO:0016740

GO:0022607

GO:0034641

GO:0042802

GO:0043097

GO:0043167

GO:0044281

GO:0046104

GO:0046872

GO:0051289

GO:0065003

GO:0071897

Hs2.105097.2.S1_3p_s_at

ILMN_1806037

M15205_at

PH_hs_0022775

PH_hs_0035630

TC17001914.hg

g4507518_3p_at

g4507518_3p_x_at

Participant Of

hasComponent

TK1 tetramer [cytosol]

output

TK1 gene expression is stimulated by E2F1

Inferred To

thk-1 [cytosol] (Caenorhabditis elegans)

tk1 [cytosol] (Danio rerio)

tk1 [cytosol] (Xenopus tropicalis)

Tk1 [cytosol] (Mus musculus)

Tk1 [cytosol] (Rattus norvegicus)

thyB [cytosol] (Dictyostelium discoideum)

TK1 [cytosol] (Bos taurus)

TK1 [cytosol] (Canis familiaris)

TK1 [cytosol] (Gallus gallus)

TK1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_003249.3

OpenTargets

ENSG00000167900

IntEnz

2.7.1.21

GeneCards

P04183

HPA

ENSG00000167900-TK1

Ensembl

ENST00000301634, ENSP00000301634, ENSG00000167900

ZINC target

P04183

PRO

P04183

HMDB Protein

HMDBP03814

PDB

1W4R, 2WVJ, 1XBT, 2ORV

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.592	2
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q1RN33 Q1RN33			0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:A0A087WZT3 A0A087WZT3			0.556	3
UniProt:Q14194 CRMP1	4	p-Y-CRMP1 [cytosol] (R-HSA-399784) p-T509,T514,S518,S522-CRMP1 [cytosol] (R-HSA-399777) p-S522-CRMP1 [cytosol] (R-HSA-399779) CRMP1 [cytosol] (R-HSA-398120)	0.553	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.553	2
UniProt:Q15262 PTPRK	1	PTPRK [plasma membrane] (R-HSA-6785699)	0.553	2
UniProt:Q13885 TUBB2A	6	TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) TUBB2A unfolded [cytosol] (R-HSA-392776) TUBB2A folding intermediate [cytosol] (R-HSA-392802)	0.553	2
UniProt:Q9UKR5 ERG28			0.553	2
UniProt:O60383 GDF9			0.553	2
UniProt:Q5RL73 RBM48			0.553	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:P51693 APLP1			0.553	2
UniProt:Q13432 U119A			0.553	2
UniProt:Q9GZT6 CC90B			0.553	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.553	2
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.553	2
UniProt:Q04724 TLE1	2	TLE1 [nucleoplasm] (R-HSA-212327) Ub-TLE1 [nucleoplasm] (R-HSA-3322369)	0.553	2

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