Reactome | TXNRD1 [cytosol]

TXNRD1 [cytosol]

Stable Identifier

R-HSA-73531

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

thioredoxin reductase 1, Thioredoxin reductase, cytoplasmic precursor (EC 1.8.1.9) (TR), Thioredoxin reductase, cytoplasmic precursor , TR, TR1

Locations in the PathwayBrowser for interactor UniProt:Q03135

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
        
        AcK-NFE2L2-dependent TXNRD1 gene expression (Homo sapiens)
        
        TXNRD1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16881 TXNRD1

Gene Names

TXNRD1, GRIM12, KDRF

Chain

chain:1-649

Reference Genes

BioGPS Gene:7296 TXNRD1

COSMIC (genes):TXNRD1 TXNRD1

CTD Gene:7296 TXNRD1

dbSNP Gene:7296 TXNRD1

ENSEMBL:ENSG00000198431 TXNRD1

ENSEMBL_homo_sapiens_GENE:ENSG00000198431.18 TXNRD1

HGNC:12437 TXNRD1

KEGG Gene (Homo sapiens):7296 TXNRD1

Monarch:7296 TXNRD1

NCBI Gene:7296 TXNRD1

OMIM:601112 TXNRD1

UCSC:Q16881 TXNRD1

Reference Transcript

Other Identifiers

11715649_s_at

11715650_a_at

11750416_a_at

16756163

201266_PM_at

201266_at

3429463

3429467

3429469

3429475

3429476

3429477

3429481

3429483

3429485

3429490

3429491

3429492

3429493

3429494

3429495

3429496

3429497

3429498

3429500

3429501

3429502

3429504

3429505

3429506

3429508

3429509

3429512

3429518

3429519

3429520

3429521

3429550

39425_at

7296

7958174

A_14_P119962

A_14_P132701

A_23_P204581

A_33_P3351120

GE60139

GO:0000166

GO:0001650

GO:0001707

GO:0003824

GO:0004791

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0006979

GO:0007165

GO:0007369

GO:0008283

GO:0010035

GO:0016209

GO:0016491

GO:0016668

GO:0023052

GO:0042802

GO:0043226

GO:0045454

GO:0048856

GO:0050137

GO:0050660

GO:0070062

GO:0071949

GO:0098754

GO:0098869

GO:0140096

HMNXSV003004085

ILMN_1717056

ILMN_2324421

PH_hs_0025324

TC12000810.hg

X91247_at

g4507746_3p_at

Participates

as an output of

as a component of

TNXRD1:FAD dimer [cytosol] (Homo sapiens)

This entity regulates

Positively

DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)

Inferred To

TXNRD1 [cytosol] (Bos taurus)

TXNRD1 [cytosol] (Caenorhabditis elegans)

TXNRD1 [cytosol] (Gallus gallus)

TXNRD1 [cytosol] (Mus musculus)

TXNRD1 [cytosol] (Plasmodium falciparum)

TXNRD1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_877419.1, NP_001248375.1, NP_877393.1, NP_001248374.1, NP_877420.1, NP_001087240.1, NP_003321.3

OpenTargets

ENSG00000198431

ZINC - Substances

TRXR1_HUMAN

ZINC target

Q16881

PRO

Q16881

PDB

2CFY, 3QFA, 7X1R, 2ZZB, 2J3N, 2ZZC, 2ZZ0, 3QFB

IntEnz

1.8.1.9

GeneCards

Q16881

HPA

ENSG00000198431-TXNRD1

Ensembl

ENSP00000421934, ENST00000526390, ENSP00000435123, ENSG00000198431, ENST00000526950, ENST00000525566, ENST00000524698, ENST00000503506, ENST00000526691, ENSP00000435929, ENSP00000432812, ENST00000529546, ENSP00000433425, ENSP00000434516, ENSP00000434919

Pharos - Targets

Q16881

Orphanet

25012

HMDB Protein

HMDBP00134

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.632	4