orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2

Stable Identifier
R-HSA-73564
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
Locations in the PathwayBrowser
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The decarboxylation of orotidine 5'-monophosphate (OMP) to form uridine 5'-monophosphate (UMP) is catalyzed by the orotidine 5'-phosphate decarboxylase activity of the bifunctional "uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine 5'-decarboxylase)" protein. While purified human protein has not been characterized in detail, the close similarity of the human gene to that encoding the well-studied hamster protein, and the demonstration that mutations in the human gene are associated with failure to convert orotate to UMP in vivo, provide convincing evidence that the human uridine monophosphate synthetase protein indeed catalyzes these two reactions (McClard et al. 1980; Suchi et al. 1997). The active form of the human protein is a dimer (Yablonski et al. 1996; Wittmann et al. 2008).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
orotidine-5'-phosphate decarboxylase activity of UMPS dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created