SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP

Stable Identifier
R-HSA-735702
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The human gene SLC35A2 encodes the UDP-galactose transporter (Miura et al. 1996). It is located on the Golgi membrane and mediates the antiport of UDP-Gal into the Golgi lumen in exchange for UMP. This transporter is also known to transport UDP-N-acetylgalactosamine (UDP-GalNAc) by the same antiport mechanism (Segawa et al. 2002).

Literature References
PubMed ID Title Journal Year
11784306 Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose

Segawa, H, Kawakita, M, Ishida, N

Eur J Biochem 2002
8889805 Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator

Miura, N, Ishida, N, Hoshino, M, Yamauchi, M, Hara, T, Ayusawa, D, Kawakita, M

J Biochem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
UDP-galactose transmembrane transporter activity of SLC35A2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed