SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP

Stable Identifier
R-HSA-735702
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human gene SLC35A2 encodes the UDP-galactose transporter (Miura et al. 1996). It is located on the Golgi membrane and mediates the antiport of UDP-Gal into the Golgi lumen in exchange for UMP. This transporter is also known to transport UDP-N-acetylgalactosamine (UDP-GalNAc) by the same antiport mechanism (Segawa et al. 2002).

Literature References
PubMed ID Title Journal Year
11784306 Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose

Segawa, H, Kawakita, M, Ishida, N

Eur J Biochem 2002
8889805 Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator

Miura, N, Ishida, N, Hoshino, M, Yamauchi, M, Hara, T, Ayusawa, D, Kawakita, M

J Biochem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
UDP-galactose transmembrane transporter activity of SLC35A2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created