SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP

Stable Identifier
R-HSA-735702
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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General
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The human gene SLC35A2 encodes the UDP-galactose transporter (Miura et al. 1996). It is located on the Golgi membrane and mediates the antiport of UDP-Gal into the Golgi lumen in exchange for UMP. This transporter is also known to transport UDP-N-acetylgalactosamine (UDP-GalNAc) by the same antiport mechanism (Segawa et al. 2002).
Literature References
PubMed ID Title Journal Year
8889805 Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator

Ishida, N, Miura, N, Ayusawa, D, Hara, T, Yamauchi, M, Kawakita, M, Hoshino, M

J Biochem 1996
11784306 Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose

Ishida, N, Segawa, H, Kawakita, M

Eur J Biochem 2002
Participants
Participates
Catalyst Activity

UDP-galactose transmembrane transporter activity of SLC35A2 [Golgi membrane]

Orthologous Events
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