uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

Stable Identifier
R-HSA-73585
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
reduction of uracil to form dihydrouracil
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of uracil and NADPH + H+ to form 5,6-dihydrouracil and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).

Literature References
PubMed ID Title Journal Year
8083224 cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria

Yokota, H, Fernandez-Salguero, P, Furuya, H, Lin, K, McBride, OW, Podschun, B, Schnackerz, KD, Gonzalez, FJ

J Biol Chem 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created