Reactome: A Curated Pathway Database

(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)

Stable Identifier
R-HSA-73598
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
phosphorylation of 2'-Deoxycytidine to 2'-Deoxycytidine 5'-phosphate
Locations in the PathwayBrowser
Summation

Cytosolic deoxycytidine kinase (DCK) catalyzes the reactions of cytidine or deoxycytidine with ATP to form CMP or dCMP and ADP. The enzyme is a homodimer (Sabini et al. 2003). Although a chimeric deoxycytidine kinase - green fluorescent protein expressed at high levels in cultured cells localized to nuclei, endogenous protein is primarily cytosolic (Hatzis et al. 1998). Despite its name, the enzyme has a broad substrate specificity, acting on cytidine, deoxycytidine, deoxyguanosine, and deoxyadenosine (Bohman and Eriksson 1988; Datta et al. 1989a, b; Sarup et al. 1989; Usova and Eriksson 2002). While ATP functions efficiently as a phosphate donor, other nucleoside triphosphates, notably UTP, function efficiently as phosphate donors in vitro and may function in this way in vivo as well (Shewach et al. 1992).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
nucleoside kinase activity of DCK dimer [cytosol] DCK dimer [cytosol] nucleoside kinase activity (0019206)
Orthologous Events