cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]

Stable Identifier
R-HSA-73599
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic uridine-cytidine kinase 1 (UCK1) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Unpublished crystallographic data show the enzyme to be a tetramer (PDB - 2JEO).

Literature References
PubMed ID Title Journal Year
11306702 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases

Van Rompay, AR, Norda, A, Linden, K, Johansson, M, Karlsson, A

Mol Pharmacol 2001
195585 Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma

Greenberg, N, Schumm, DE, Webb, TE

Biochem J 1977
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleoside kinase activity of UCK1 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Created