dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

Stable Identifier
R-HSA-73605
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
conversion of dUMP to dTMP
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Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).

Literature References
PubMed ID Title Journal Year
11278511 Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors

Phan, J, Steadman, DJ, Koli, S, Ding, WC, Minor, W, Dunlap, RB, Berger, SH, Lebioda, L

J Biol Chem 2001
2656695 Expression of human thymidylate synthase in Escherichia coli

Davisson, VJ, Sirawaraporn, W, Santi, DV

J Biol Chem 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thymidylate synthase activity of TS dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Created