Reactome: A Curated Pathway Database

(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)

Stable Identifier
R-HSA-73608
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Synonyms
deamination of 2'-Deoxycytidine to 2'-Deoxyuridine
Locations in the PathwayBrowser
Summation

Cytosolic cytidine deaminase catalyzes the hydrolysis of cytidine or dexoycytidine to form uridine or deoxyuridine and ammonia (Laliberte and Momparler 1994). The active form of the enzyme is a tetramer (Chung et al. 2005).

Literature References
PubMed ID Title Journal Year
15689149 Structure of human cytidine deaminase bound to a potent inhibitor J Med Chem 2005
7923172 Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA Cancer Res 1994
Participants
input
output
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
cytidine deaminase activity of CDA tetramer [cytosol] CDA tetramer [cytosol] cytidine deaminase activity (0004126)
Orthologous Events
 
Follow Reactome