(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)

Stable Identifier
R-HSA-73608
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Synonyms
deamination of 2'-Deoxycytidine to 2'-Deoxyuridine
Locations in the PathwayBrowser
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Summation

Cytosolic cytidine deaminase catalyzes the hydrolysis of cytidine or dexoycytidine to form uridine or deoxyuridine and ammonia (Laliberte and Momparler 1994). The active form of the enzyme is a tetramer (Chung et al. 2005).

Literature References
PubMed ID Title Journal Year
15689149 Structure of human cytidine deaminase bound to a potent inhibitor

Chung, SJ, Fromme, JC, Verdine, GL

J Med Chem 2005
7923172 Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA

Laliberte, J, Momparler, RL

Cancer Res 1994
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cytidine deaminase activity of CDA tetramer [cytosol]
Physical Entity
CDA tetramer [cytosol]
Activity
cytidine deaminase activity (0004126)
Orthologous Events
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Gallus gallus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Schizosaccharomyces pombe)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Taeniopygia guttata)
Cross References
Rhea