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RRM2 [cytosol]
Stable Identifier
R-HSA-73639
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ribonucleotide reductase M2 polypeptide, Ribonucleoside-diphosphate reductase M2 chain (EC 1.17.4.1) (Ribonucleotide reductase small chain), Ribonucleoside-diphosphate reductase M2 chain , Ribonucleotide reductase small chain
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
RRM2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
RRM2 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
RNR (M1M2) [cytosol] (Homo sapiens)
RRM2 dimer [cytosol] (Homo sapiens)
RRM2 [cytosol] (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
RNR (M1M2) [cytosol] (Homo sapiens)
RRM2 dimer [cytosol] (Homo sapiens)
RRM2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31350 RRM2
Gene Names
RRM2, RR2
Chain
chain:1-389
Reference Genes
BioGPS Gene:6241 RRM2
COSMIC (genes):RRM2 RRM2
CTD Gene:6241 RRM2
dbSNP Gene:6241 RRM2
ENSEMBL:ENSG00000171848 RRM2
HGNC:10452 RRM2
KEGG:hsa:6241 RRM2
Monarch:6241 RRM2
NCBI Gene:6241 RRM2
OMIM:180390 RRM2
UCSC:P31350 RRM2
Reference Transcript
RefSeq:NM_001165931.1 RRM2
RefSeq:NM_001034.3 RRM2
Other Identifiers
11737686_at
11737687_at
11754360_a_at
11758219_x_at
16877019
16877041
201890_PM_at
201890_at
209773_PM_s_at
209773_s_at
2440825
2469251
2469253
2469254
2469255
2469256
2469257
2469258
2469259
2469260
2469261
2469262
2469263
2469264
2469265
2469266
2469267
2469269
2469270
2469271
2469273
2469274
2469275
2469276
2469277
2469278
2469279
2469280
2469281
2469284
2469287
2469297
2469298
2469299
2469300
2469301
2469303
2469304
2469305
2469309
2469311
2469315
2469345
36922_at
4006364
4006368
6241
77842_at
8040223
8040231
A_14_P101945
A_14_P120837
A_14_P131994
A_21_P0000205
A_24_P225616
A_24_P234196
A_24_P6764
A_33_P3286372
GE546218
GE576460
GE59846
GO:0001824
GO:0003824
GO:0004748
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005971
GO:0008199
GO:0009185
GO:0009262
GO:0009263
GO:0009265
GO:0016491
GO:0042802
GO:0042803
GO:0043226
GO:0046872
GO:0048856
GO:0051290
GO:0055086
GO:0065003
GO:1900087
GO:1901135
HMNXSV003027599
HMNXSV003049318
Hs.75319.0.S3_3p_at
ILMN_1678669
ILMN_1720833
PH_hs_0023142
PH_hs_0026316
TC02000057.hg
TC02000058.hg
X59618_at
g12804874_3p_a_at
Participates
as an output of
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
as a component of
RRM2 dimer [cytosol] (Homo sapiens)
Inferred To
rrm2.2 [cytosol]
(Xenopus tropicalis)
RRM2 [cytosol]
(Bos taurus)
RRM2 [cytosol]
(Caenorhabditis elegans)
RRM2 [cytosol]
(Canis familiaris)
RRM2 [cytosol]
(Danio rerio)
RRM2 [cytosol]
(Dictyostelium discoideum)
RRM2 [cytosol]
(Drosophila melanogaster)
RRM2 [cytosol]
(Mus musculus)
RRM2 [cytosol]
(Plasmodium falciparum)
RRM2 [cytosol]
(Rattus norvegicus)
RRM2 [cytosol]
(Saccharomyces cerevisiae)
RRM2 [cytosol]
(Schizosaccharomyces pombe)
RRM2 [cytosol]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
2631
ENSEMBL
ENST00000641198
,
ENST00000360566
,
ENSP00000493399
,
ENSP00000302955
,
ENST00000304567
,
ENSP00000353770
OpenTargets
ENSG00000171848
HPA
ENSG00000171848-RRM2
ZINC - Substances
RIR2_HUMAN
ZINC target
P31350
PRO
P31350
Pharos - Targets
P31350
GlyGen
P31350
ZINC - Predictions - Purchasable
RIR2_HUMAN
HMDB Protein
HMDBP00111
PDB
3VPM
,
2UW2
,
3OLJ
,
3VPO
,
3VPN
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23921 RRM1
1
RRM1 [cytosol]
(R-HSA-73638)
0.85
7
UniProt:P41002 CCNF
1
CCNF [cytosol]
(R-HSA-8862602)
0.628
12
UniProt:Q9UM11 FZR1
4
FZR1 [cytosol]
(R-HSA-174249)
FZR1 [nucleoplasm]
(R-HSA-174099)
p-FZR1 [nucleoplasm]
(R-HSA-174257)
p-FZR1 [cytosol]
(R-HSA-174193)
0.623
7
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.527
3
UniProt:Q96CS3 FAF2
3
FAF2 [cytosol]
(R-HSA-6781921)
FAF2 [extracellular region]
(R-HSA-6806183)
FAF2 [azurophil granule lumen]
(R-HSA-6799138)
0.527
2
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [cytosol]
(R-HSA-174168)
ANAPC4 [nucleoplasm]
(R-HSA-174115)
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
2
UniProt:O15357 INPPL1
1
INPPL1 [cytosol]
(R-HSA-913354)
0.527
2
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