RNA Polymerase I Promoter Opening

Stable Identifier
R-HSA-73728
Type
Pathway
Species
Homo sapiens
Compartment
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The activity of the upstream binding factor (UBF-1) plays an important role in the regulation of rRNA synthesis. Studies reveal that phosphorylation of UBF-1 is required for its interaction with the RNA polymerase I complex, suggesting that phosphorylation of UBF-1 bound to the rDNA promoter during promoter opening modulates the assembly of the transcription initiation complex.

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Event Information
Orthologous Events
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