Acetylation of SL1

Stable Identifier
R-HSA-73736
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Acetylation of the TAFI63 subunit of SL1 by PCAF stimulates the association of TAFI63 with DNA and stimulates pol I transcription in vitro. Conversely, deacetylation by the NAD+-dependent deacetylase Sir2 represses pol I transcription.

Literature References
PubMed ID Title Journal Year
11250901 Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.

Muth, V, Nadaud, S, Grummt, I, Voit, R

EMBO J 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acetyltransferase activity of PCAF [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Created