RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

Stable Identifier
R-HSA-73779
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Formation of the pre-initiation complex proceeds in five steps, recognition and binding of core promoter elements by TFIID, binding of TFIIA and TFIIB to the pol II promoter:TFIID complex, recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex, binding of TFIIE to the growing preinitiation complex, and formation of the closed pre-initiation complex (Orphanides et al. 1997).

Literature References
PubMed ID Title Journal Year
8946909 The general transcription factors of RNA polymerase II.

Orphanides, G, Lagrange, T, Reinberg, D

Genes Dev 1997
Participants
Participant Of
Event Information
Orthologous Events
Authored
Created