(d)GMP + ATP <=> (d)GDP + ADP (GUK1)

Stable Identifier
R-HSA-73788
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic guanylate kinase 1 (GUK1) catalyzes the reversible reactions of GMP and dGMP with ATP to form GDP and dGDP respectively and ADP. While native gel electrophoretic studies of whole cell extracts suggested the existence of multiple human enzymes with guanylate kinase activity (Jamil et al. 1975), only one has been purified and biochemically characterized (Agarwal et al. 1978; Brady et al. 1996). The enzyme is of clinical importance as it is a target of antitumor drugs and antiviral drugs such as acyclovir (Miller and Miller 1980).

Literature References
PubMed ID Title Journal Year
177353 Studies on the properties and tissue distribution of the isozymes of guanylate kinase in man

Jamil, T, Fisher, RA, Harris, H

Human Hered 1975
6248551 Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase

Miller, WH, Miller, RL

J Biol Chem 1980
211390 Guanylate kinases from human erythrocytes, hog brain, and rat liver

Agarwal, KC, Miech, RP, Parks, Jr, RE

Methods Enzymol 1978
8663313 Cloning, characterization, and modeling of mouse and human guanylate kinases

Brady, WA, Kokoris, MS, Fitzgibbon, M, Black, ME

J Biol Chem 1996
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
guanylate kinase activity of GUK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created