XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate

Stable Identifier
R-HSA-73792
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate
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Cytosolic GMP synthase (GMPS) catalyzes the reaction of xanthosine 5'-monophosphate (XMP), ATP, glutamine and water to form guanosine 5'-monophosphate (GMP), AMP, glutamate and pyrophosphate. GMPS is a monomer (Hirst et al. 1994; Nakamura and Lou 1995).

Literature References
PubMed ID Title Journal Year
8089153 Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA

Hirst, M, Haliday, E, Nakamura, J, Lou, L

J Biol Chem 1994
7706277 Biochemical characterization of human GMP synthetase

Nakamura, J, Lou, L

J Biol Chem 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GMP synthase (glutamine-hydrolyzing) activity of GMPS [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created