AIR + CO2 => CAIR

Stable Identifier
R-HSA-73806
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
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The reversible carboxylation of 5'-phosphoribosyl-5-aminoimidazole (AIR) to form 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) is catalyzed by the phosphoribosylaminoimidazole carboxylase domain of the bifunctional protein "phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase" (PAICS) (Schild et al. 1990). The enzyme is an octamer (Li et al. 2007); it may associate in the cytosol with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References
PubMed ID Title Journal Year
2183217 Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations

Schild, D, Brake, AJ, Kiefer, MC, Young, D, Barr, PJ

Proc Natl Acad Sci USA 1990
18388293 Reversible compartmentalization of de novo purine biosynthetic complexes in living cells

An, S, Kumar, R, Sheets, ED, Benkovic, SJ

Science 2008
17224163 Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis

Li, SX, Tong, YP, Xie, XC, Wang, QH, Zhou, HN, Han, Y, Zhang, ZY, Gao, W, Li, SG, Zhang, XC, Bi, RC

J Mol Biol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoribosylaminoimidazole carboxylase activity of PAICS octamer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created
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