FGAM + ATP => AIR + ADP + Pi

Stable Identifier
R-HSA-73810
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate
Locations in the PathwayBrowser
Summation

The irreversible synthesis of cytosolic 5'-phosphoribosyl-5-aminoimidazole (AIR) from 5'-phosphoribosylformylglycinamidine (FGAM), accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylaminoimidazole synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic and may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (Gooljarsingh et al. 2001; An et al. 2008).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoribosylformylglycinamidine cyclo-ligase activity of GART [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea