acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH

Stable Identifier
R-HSA-73918
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Hydroxymethylglutaryl-CoA synthase tetramer (HMGCS2) in the mitochondrial matrix catalyzes the reaction of acetoacetyl-CoA and acetyl-CoA to form beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) and CoA (Aledo et al. 2001).

Literature References
PubMed ID Title Journal Year
11479731 Genetic basis of mitochondrial HMG-CoA synthase deficiency

Aledo, R, Zschocke, J, Pie, J, Mir, C, Fiesel, S, Mayatepek, E, Hoffmann, GF, Casals, N, Hegardt, FG

Hum Genet 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydroxymethylglutaryl-CoA synthase activity of HMGCS2 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Created