acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH

Stable Identifier
R-HSA-73918
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hydroxymethylglutaryl-CoA synthase tetramer (HMGCS2) in the mitochondrial matrix catalyzes the reaction of acetoacetyl-CoA and acetyl-CoA to form beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) and CoA (Aledo et al. 2001).
Literature References
PubMed ID Title Journal Year
11479731 Genetic basis of mitochondrial HMG-CoA synthase deficiency

Hoffmann, GF, Casals, N, Pie, J, Aledo, R, Hegardt, FG, Zschocke, J, Mayatepek, E, Fiesel, S, Mir, C

Hum Genet 2001
Participants
Participates
Catalyst Activity

hydroxymethylglutaryl-CoA synthase activity of HMGCS2 [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Created
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