Depurination

Stable Identifier
R-HSA-73927
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Pathway
Species
Homo sapiens
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Depurination of a damaged nucleotide is mediated by a purine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, generating a free base and an abasic i.e. apurinic/apyrimidinic (AP) site (Slupphaug et al. 1996, Parikh et al. 1998).

Literature References
PubMed ID Title Journal Year
9724657 Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA

Parikh, SS, Mol, CD, Slupphaug, G, Bharati, S, Krokan, HE, Tainer, JA

EMBO J 1998
8900285 A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

Slupphaug, G, Mol, CD, Kavli, B, Arvai, AS, Krokan, HE, Tainer, JA

Nature 1996
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