Depyrimidination

Stable Identifier
R-HSA-73928
Type
Pathway
Species
Homo sapiens
Compartment
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Depyrimidination of a damaged nucleotide in DNA is mediated by a pyrimidine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar generating a free base and an abasic i.e. apurinic/apyrimidinic (AP) site (Lindahl and Wood 1999).

Literature References
PubMed ID Title Journal Year
10583946 Quality control by DNA repair

Lindahl, T, Wood, RD

Science 1999
Participants
Participant Of
Event Information
Go Biological Process
Orthologous Events
Authored
Reviewed
Created