Abasic sugar-phosphate removal via the single-nucleotide replacement pathway

Stable Identifier
R-HSA-73930
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Abasic sugar phosphate removal via the single nucleotide replacement pathway requires displacement of DNA glycosylase by APEX1, APEX1-mediated endonucleolytic cleavage at the 5' side of the base free deoxyribose residue, recruitment of POLB to the AP site and excision of the abasic sugar phosphate (5'dRP) residue at the strand break (Lindahl and Wood, 1999).

Literature References
PubMed ID Title Journal Year
10583946 Quality control by DNA repair

Lindahl, T, Wood, RD

Science 1999
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created