Abasic sugar-phosphate removal via the single-nucleotide replacement pathway

Stable Identifier
R-HSA-73930
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
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Abasic sugar phosphate removal via the single nucleotide replacement pathway requires displacement of DNA glycosylase by APEX1, APEX1-mediated endonucleolytic cleavage at the 5' side of the base free deoxyribose residue, recruitment of POLB to the AP site and excision of the abasic sugar phosphate (5'dRP) residue at the strand break (Lindahl and Wood, 1999).
Literature References
PubMed ID Title Journal Year
10583946 Quality control by DNA repair

Lindahl, T, Wood, RD

Science 1999
Participants
Events
Participates
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Event Information
Go Biological Process
base-excision repair (0006284)
Orthologous Events
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Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Danio rerio)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Dictyostelium discoideum)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Mus musculus)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Rattus norvegicus)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Sus scrofa)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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