OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA

Stable Identifier
R-HSA-74177
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate
Locations in the PathwayBrowser
Summation

Mitochondrial succinyl-CoA:3-ketoacid coenzyme A transferases 1 and 2 (OXCT1 and OXCT2) are key enzymes for the metabolism of ketone bodies, catalysing the first rate-limiting step of ketone body utilisation in peripheral tissues. In dimeric form, they mediate the transfer of a CoA moiety from succinyl-CoA (SUCC-CoA) to acetoacetate (ACA) to form acetoacetyl-CoA (ACA-CoA) and succinate (SUCCA) (Kassovska-Bratinova et al. 1996, Tanaka et al. 2002). ACA-CoA can be converted to acetyl-CoA which can be utilised by the tricarboxylic acid cycle for energy production.

Literature References
PubMed ID Title Journal Year
11756565 Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA

Tanaka, H, Kohroki, J, Iguchi, N, Onishi, M, Nishimune, Y

Mol. Hum. Reprod. 2002
8751852 Succinyl CoA: 3-oxoacid CoA transferase (SCOT): human cDNA cloning, human chromosomal mapping to 5p13, and mutation detection in a SCOT-deficient patient

Kassovska-Bratinova, S, Fukao, T, Song, XQ, Duncan, AM, Chen, HS, Robert, MF, Pérez-Cerda, C, Ugarte, M, Chartrand, C, Vobecky, S, Kondo, N, Mitchell, GA

Am J Hum Genet 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-oxoacid CoA-transferase activity of OXCT dimers [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored