guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)

Stable Identifier
R-HSA-74215
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic hypoxanthine-guanine phosphoribosyltransferase (HPRT1) tetramer catalyzes the reactions of guanine or hypoxanthine with PRPP to form GMP ir IMP and pyrophosphate (Holden and Kelley 1978; Jolly et al. 1983).

Literature References
PubMed ID Title Journal Year
6300847 Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

Jolly, DJ, Okayama, H, Berg, P, Esty, AC, Filpula, D, Bohlen, P, Johnson, GG, Shively, JE, Hunkapillar, T, Friedmann, T

Proc Natl Acad Sci U S A 1983
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
hypoxanthine phosphoribosyltransferase activity of HGPRT tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created