SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen

Stable Identifier
R-HSA-742345
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene SLC35C1 encodes the GDP-fucose transporter FUCT1. It resides on the Golgi membrane and mediates the transport of GDP-fucose (GDP-Fuc) formed from a de novo pathway and/or a salvage pathway into the Golgi lumen. Defects in SLC35C1 causes the congenital disorder of glycosylation type 2C, also known as leukocyte adhesion deficiency type II (LAD2) (Lubke et al. 2001).

Literature References
PubMed ID Title Journal Year
11326280 Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency

Lübke, T, Marquardt, T, Etzioni, A, Hartmann, E, von Figura, K, Körner, C

Nat Genet 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GDP-fucose transmembrane transporter activity of SLC35C1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created