(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)

Stable Identifier
R-HSA-74241
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer.

Literature References
PubMed ID Title Journal Year
3182793 Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts

Akeson, AL, Wiginton, DA, Dusing, MR, States, JC, Hutton, JJ

J Biol Chem 1988
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
adenosine deaminase activity of ADA [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created