Guanine + H2O => Xanthine + NH4+

Stable Identifier
R-HSA-74255
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic guanine deaminase (GDA) catalyzes the reaction of guanine and water to form xanthine and ammonia (Yuan et al. 1999). The active enzyme is a homodimer (Murphy et al. 2009).

Literature References
PubMed ID Title Journal Year
10075721 Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein.

Yuan, G, Bin, JC, McKay, DJ, Snyder, FF

J Biol Chem 1999
19470646 Alteration of enzyme specificity by computational loop remodeling and design

Murphy, PM, Bolduc, JM, Gallaher, JL, Stoddard, BL, Baker, D

Proc Natl Acad Sci U S A 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanine deaminase activity of GDA dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created