uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]

Stable Identifier
R-HSA-74372
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic uridine phosphorylase (isoforms UPP1 and UPP2) catalyzes the reversible reactions of uracil with ribose 1-phosphate or deoxyribose 1-phosphate to yield uridine or deoxyuridine and orthophosphate (Watanabe and Uchida 1995; Johansson, 2003). The active form of UPP1 is a dimer (Rooslid et al. 2009).

Literature References
PubMed ID Title Journal Year
19291308 Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy

Roosild, TP, Castronovo, S, Fabbiani, M, Pizzorno, G

BMC Struct Biol 2009
7488099 Cloning and expression of human uridine phosphorylase

Watanabe, SI, Uchida, T

Biochem Biophys Res Commun 1995
12849978 Identification of a novel human uridine phosphorylase

Johansson, M

Biochem Biophys Res Commun 2003
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
uridine phosphorylase activity of UPP1, UPP2 [cytosol]
Physical Entity
Activity
Orthologous Events