Reactome: A Curated Pathway Database

uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]

Stable Identifier
R-HSA-74372
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic uridine phosphorylase (isoforms UPP1 and UPP2) catalyzes the reversible reactions of uracil with ribose 1-phosphate or deoxyribose 1-phosphate to yield uridine or deoxyuridine and orthophosphate (Watanabe and Uchida 1995; Johansson, 2003). The active form of UPP1 is a dimer (Rooslid et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
uridine phosphorylase activity of UPP1, UPP2 [cytosol] UPP1, UPP2 [cytosol] uridine phosphorylase activity (0004850)
Orthologous Events