SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP

Stable Identifier
R-HSA-744230
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the antiport of GDP-mannose into the Golgi lumen in exchange for GMP (Suda T et al, 2004; Ishida N et al, 2005).

Literature References
PubMed ID Title Journal Year
15082721 Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection

Suda, T, Kamiyama, S, Suzuki, M, Kikuchi, N, Nakayama, K, Narimatsu, H, Jigami, Y, Aoki, T, Nishihara, S

J Biol Chem 2004
15607426 Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family

Ishida, N, Kuba, T, Aoki, K, Miyatake, S, Kawakita, M, Sanai, Y

Genomics 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleotide-sugar transmembrane transporter activity of SLC35D2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created