SLC35D2 exchanges UDP-sugars for UMP

Stable Identifier
R-HSA-744231
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the transport of nucleotide sugars such as UDP-GlcNAc and UDP-glucose into the Golgi lumen in exchange for UMP (Suda et al. 2004, Ishida et al. 2005).

Literature References
PubMed ID Title Journal Year
15082721 Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection

Suda, T, Kamiyama, S, Suzuki, M, Kikuchi, N, Nakayama, K, Narimatsu, H, Jigami, Y, Aoki, T, Nishihara, S

J Biol Chem 2004
15607426 Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family

Ishida, N, Kuba, T, Aoki, K, Miyatake, S, Kawakita, M, Sanai, Y

Genomics 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleotide-sugar transmembrane transporter activity of SLC35D2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed