Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Stable Identifier
R-HSA-744887
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The role of the guanine nucleotide-binding protein G alpha-s subunit (G alpha-s) (Kozasa T et al, 1988) is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn, activates cAMP-dependent protein kinase.

Literature References
PubMed ID Title Journal Year
12036966 Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus

Feldman, DS, Zamah, AM, Pierce, KL, Miller, WE, Kelly, F, Rapacciuolo, A, Rockman, HA, Koch, WJ, Luttrell, LM

J Biol Chem 2002
Participants
Participant Of
Authored
Reviewed
Created