Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs

Stable Identifier
R-HSA-744887
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
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The role of the guanine nucleotide-binding protein G alpha-s subunit (G alpha-s) (Kozasa T et al, 1988) is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn, activates cAMP-dependent protein kinase.

Literature References
PubMed ID Title Journal Year
12036966 Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus

Feldman, DS, Luttrell, LM, Pierce, KL, Kelly, F, Koch, WJ, Rapacciuolo, A, Miller, WE, Zamah, AM, Rockman, HA

J Biol Chem 2002
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Authored
Jupe, S  (2010-05-18)
Reviewed
D'Eustachio, P  (2010-05-22)
Created
Jupe, S  (2010-05-18)
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