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INSR(763-1382) [plasma membrane]
Stable Identifier
R-HSA-74669
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
insulin receptor beta subunit
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Autophosphorylation of insulin receptor (Homo sapiens)
Insulin:Insulin receptor [plasma membrane] (Homo sapiens)
Insulin receptor [plasma membrane] (Homo sapiens)
INSR(763-1382) [plasma membrane] (Homo sapiens)
Insulin binds the insulin receptor (Homo sapiens)
Insulin receptor [plasma membrane] (Homo sapiens)
INSR(763-1382) [plasma membrane] (Homo sapiens)
Insulin:Insulin receptor [plasma membrane] (Homo sapiens)
Insulin receptor [plasma membrane] (Homo sapiens)
INSR(763-1382) [plasma membrane] (Homo sapiens)
Insulin receptor recycling (Homo sapiens)
Re-integration of insulin receptor into plasma membrane (Homo sapiens)
Insulin receptor [plasma membrane] (Homo sapiens)
INSR(763-1382) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06213 INSR
Gene Names
INSR
Chain
signal peptide:1-27, chain:28-758, chain:763-1382
Reference Genes
BioGPS Gene:3643 INSR
COSMIC (genes):INSR INSR
CTD Gene:3643 INSR
dbSNP Gene:3643 INSR
ENSEMBL:ENSG00000171105 INSR
HGNC:6091 INSR
KEGG Gene (Homo sapiens):3643 INSR
Monarch:3643 INSR
NCBI Gene:3643 INSR
OMIM:147670 INSR
UCSC:P06213 INSR
Reference Transcript
RefSeq:NM_001079817.2 INSR
RefSeq:NM_000208.3 INSR
Other Identifiers
0002370519
11720856_a_at
11720857_a_at
11720858_a_at
11740017_a_at
11740018_a_at
1572_s_at
16867915
1GAG
1I44
1IR3
1IRK
1P14
1RQQ
207851_s_at
213792_s_at
226212_s_at
226216_at
226450_at
2AUH
2B4S
2HR7
2MFR
2Z8C
33162_at
36302
36303
3643
3848249
3848250
3848251
3848252
3848253
3848254
3848255
3848256
3848257
3848258
3848259
3848260
3848262
3848263
3848264
3848266
3848267
3848268
3848269
3848270
3848271
3848273
3848278
3848279
3848280
3848281
3848282
3848288
3848292
3848293
3848294
3848296
3848297
3848299
3848301
3848303
3848304
3848308
3848341
3848349
3848350
3BU3
3BU5
3BU6
3EKK
3EKN
3ETA
3W11
3W12
3W13
47628_at
4IBM
4OGA
4XLV
4XSS
4XST
4ZXB
5E1S
5HHW
5J3H
5KQV
5U1M
65110_at
6HN4
6HN5
8033362
A_23_P4764
A_33_P3335725
AAA59174
AAA59175
AAA59176
AAA59177
AAA59178
AAA59190
AAA59452
AAA86791
AAC37604
AAI17173
AB208861
AC010311
AC010526
AC010606
AC125387
BAD92098
BC117172
CAA26096
CCDS12176
CCDS42487
ENSG00000171105
ENSP00000303830
ENSP00000342838
ENST00000302850
ENST00000302850.9
ENST00000341500
ENST00000341500.9
EntrezGene:3643
EntrezGene:INSR
g4557883_3p_a_at
GE59638
GO:0000003
GO:0000166
GO:0000187
GO:0000278
GO:0001540
GO:0001934
GO:0003007
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005009
GO:0005159
GO:0005515
GO:0005524
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005737
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005886
GO:0005887
GO:0005899
GO:0005901
GO:0005975
GO:0006091
GO:0006355
GO:0006464
GO:0006468
GO:0006810
GO:0006898
GO:0007049
GO:0007165
GO:0007169
GO:0007186
GO:0007612
GO:0007613
GO:0008150
GO:0008283
GO:0008284
GO:0008286
GO:0008544
GO:0008584
GO:0009056
GO:0009058
GO:0009790
GO:0009887
GO:0009897
GO:0010008
GO:0014068
GO:0016020
GO:0016021
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019087
GO:0019904
GO:0022607
GO:0030238
GO:0030325
GO:0030335
GO:0030424
GO:0031017
GO:0031410
GO:0031981
GO:0031994
GO:0031995
GO:0032147
GO:0032148
GO:0032590
GO:0032809
GO:0032869
GO:0032991
GO:0034641
GO:0038024
GO:0038083
GO:0040007
GO:0040011
GO:0042592
GO:0042593
GO:0043167
GO:0043226
GO:0043235
GO:0043243
GO:0043410
GO:0043548
GO:0043559
GO:0043560
GO:0044281
GO:0044403
GO:0044877
GO:0045429
GO:0045725
GO:0045821
GO:0045840
GO:0045893
GO:0045995
GO:0046326
GO:0046777
GO:0048639
GO:0048856
GO:0048870
GO:0050877
GO:0051290
GO:0051425
GO:0051446
GO:0051897
GO:0055085
GO:0060267
GO:0065003
GO:0070062
GO:0071363
GO:0097062
GO:0097242
GO:0140014
GO:1990535
GO:2000194
HGNC:6091
HPA036302
HPA036303
Hs.208334.0.S1_3p_at
Hs.208334.0.S2_3p_s_at
Hs.89695.2.A1_3p_at
Hs.98401.0.S1_3p_at
ILMN_1670918
INSR
INSR-201
INSR-202
IPR000494
IPR000719
IPR001245
IPR002011
IPR003961
IPR006211
IPR006212
IPR008266
IPR009030
IPR011009
IPR013783
IPR016246
IPR017441
IPR020635
IPR036116
IPR036941
IPR040969
J03466
J05043
M0R3E6
M10051
M10051_s_at
M23100
M24555
M27195
M27197
M29929
M29930
M32823
M32824
M32825
M32826
M32827
M32828
M32829
M32830
M32831
M32832
M32833
M32834
M32835
M32836
M32837
M32838
M32839
M32840
M32841
M32842
M32972
M76592
MIM:147670
MIM:246200
MIM:262190
MIM:609968
MIM:610549
NM_000208
NM_001079817
NP_000199
NP_001073285
PF00757
PF01030
PF07714
PF17870
PH_hs_0025683
PR00109
SM00060
SM00219
SM00261
TC19001111.hg
UPI0000140EE6
UPI000020324D
X02160
X02160_at
XM_011527988
XM_011527989
XP_011526290
XP_011526291
Participant Of
hasComponent
Insulin receptor [plasma membrane]
Other forms of this molecule
p-6Y-INSR(763-1382) [endosome membrane]
INSR(763-1382) [endosome membrane]
INSR(28-758) [endosome membrane]
p-6Y-INSR(763-1382) [plasma membrane]
INSR(28-758) [plasma membrane]
Inferred To
INSR(763-1382) [plasma membrane] (Bos taurus)
INSR(763-1382) [plasma membrane] (Canis familiaris)
INSR(763-1382) [plasma membrane] (Danio rerio)
INSR(763-1382) [plasma membrane] (Drosophila melanogaster)
INSR(763-1382) [plasma membrane] (Gallus gallus)
INSR(763-1382) [plasma membrane] (Mus musculus)
INSR(763-1382) [plasma membrane] (Rattus norvegicus)
INSR(763-1382) [plasma membrane] (Sus scrofa)
INSR(763-1382) [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_001073285.1
,
NP_000199.2
ZINC - World Drugs
INSR_HUMAN
OpenTargets
ENSG00000171105
ZINC - FDA approved
INSR_HUMAN
ZINC - Substances
INSR_HUMAN
ZINC target
P06213
ZINC - Biogenic
INSR_HUMAN
PRO
P06213
PDB
4OGA
,
2B4S
,
1GAG
,
5J3H
,
6PXW
,
2MFR
,
1IR3
,
5E1S
,
3BU6
,
3W13
,
3W12
,
2AUH
,
6PXV
,
4XLV
,
5KQV
,
1P14
,
1I44
,
4ZXB
,
3BU3
,
2Z8C
,
3W11
,
4IBM
,
1IRK
,
3BU5
,
3ETA
,
1RQQ
,
4XST
,
6HN4
,
4XSS
,
6HN5
,
3EKN
,
5U1M
,
2HR7
,
3EKK
,
5HHW
ZINC - Investigational
INSR_HUMAN
ZINC - Metabolites
INSR_HUMAN
IntEnz
2.7.10.1
GeneCards
P06213
ZINC - Predictions - Purchasable
INSR_HUMAN
Orphanet
16263
HMDB Protein
HMDBP01521
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18031 PTPN1
1
PTPN1 [cytosol]
(R-HSA-210625)
0.979
32
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.799
9
UniProt:P35570 Irs1
7
p-Y-Irs1 [cytosol]
(R-RNO-112362)
Irs1 [cytosol]
(R-RNO-1168867)
phospho-p-6Y-IRS1 [plasma membrane]
(R-RNO-2445090)
IRS1 [plasma membrane]
(R-RNO-2425392)
IRS1 [cytosol]
(R-RNO-74769)
phospho-p-Y-IRS1 [cytosol]
(R-RNO-74772)
phospho-p-Y-IRS1 [plasma membrane]
(R-RNO-198366)
0.791
5
UniProt:P35568 IRS1
5
IRS1 [plasma membrane]
(R-HSA-2425392)
p-6Y-IRS1 [plasma membrane]
(R-HSA-2445090)
IRS1 [cytosol]
(R-HSA-74769)
p-Y-IRS1 [cytosol]
(R-HSA-74772)
p-Y-IRS1 [plasma membrane]
(R-HSA-198366)
0.704
5
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
0.688
3
UniProt:Q13322 GRB10
1
GRB10 [cytosol]
(R-HSA-110009)
0.581
4
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
SHC1 [cytosol]
(R-HSA-74680)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.573
2
UniProt:Q06124 PTPN11
4
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y546-PTPN11 [cytosol]
(R-HSA-1369081)
p-Y546,Y584-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
0.564
2
UniProt:Q9Y4H2 IRS2
4
IRS2 [cytosol]
(R-HSA-57528)
IRS2 [plasma membrane]
(R-HSA-2428927)
p-Y-IRS2 [cytosol]
(R-HSA-74774)
p-Y-IRS2 [plasma membrane]
(R-HSA-198334)
0.527
4
UniProt:Q99490 AGAP2
1
AGAP2 [cytosol]
(R-HSA-622355)
0.524
2
UniProt:Q13257 MAD2L1
2
Activated MAD2L1 [cytosol]
(R-HSA-141447)
MAD2L1 [cytosol]
(R-HSA-141400)
0.463
2
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