Reactome | INSR(763-1382) [plasma membrane]

INSR(763-1382) [plasma membrane]

Stable Identifier

R-HSA-74669

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

insulin receptor beta subunit

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External Reference Information

External Reference

UniProt:P06213 INSR

Gene Names

INSR

Chain

signal peptide:1-27, chain:28-758, chain:763-1382

Reference Genes

BioGPS Gene:3643 INSR

COSMIC (genes):INSR INSR

CTD Gene:3643 INSR

dbSNP Gene:3643 INSR

ENSEMBL:ENSG00000171105 INSR

HGNC:6091 INSR

KEGG Gene (Homo sapiens):3643 INSR

Monarch:3643 INSR

NCBI Gene:3643 INSR

OMIM:147670 INSR

UCSC:P06213 INSR

Reference Transcript

Other Identifiers

0002370519

11720856_a_at

11720857_a_at

11720858_a_at

11740017_a_at

11740018_a_at

1572_s_at

16867915

1GAG

1I44

1IR3

1IRK

1P14

1RQQ

207851_s_at

213792_s_at

226212_s_at

226216_at

226450_at

2AUH

2B4S

2HR7

2MFR

2Z8C

33162_at

36302

36303

3643

3848249

3848250

3848251

3848252

3848253

3848254

3848255

3848256

3848257

3848258

3848259

3848260

3848262

3848263

3848264

3848266

3848267

3848268

3848269

3848270

3848271

3848273

3848278

3848279

3848280

3848281

3848282

3848288

3848292

3848293

3848294

3848296

3848297

3848299

3848301

3848303

3848304

3848308

3848341

3848349

3848350

3BU3

3BU5

3BU6

3EKK

3EKN

3ETA

3W11

3W12

3W13

47628_at

4IBM

4OGA

4XLV

4XSS

4XST

4ZXB

5E1S

5HHW

5J3H

5KQV

5U1M

65110_at

6HN4

6HN5

8033362

A_23_P4764

A_33_P3335725

AAA59174

AAA59175

AAA59176

AAA59177

AAA59178

AAA59190

AAA59452

AAA86791

AAC37604

AAI17173

AB208861

AC010311

AC010526

AC010606

AC125387

BAD92098

BC117172

CAA26096

CCDS12176

CCDS42487

ENSG00000171105

ENSP00000303830

ENSP00000342838

ENST00000302850

ENST00000302850.9

ENST00000341500

ENST00000341500.9

EntrezGene:3643

EntrezGene:INSR

g4557883_3p_a_at

GE59638

GO:0000003

GO:0000166

GO:0000187

GO:0000278

GO:0001540

GO:0001934

GO:0003007

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0005009

GO:0005159

GO:0005515

GO:0005524

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005737

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005886

GO:0005887

GO:0005899

GO:0005901

GO:0005975

GO:0006091

GO:0006355

GO:0006464

GO:0006468

GO:0006810

GO:0006898

GO:0007049

GO:0007165

GO:0007169

GO:0007186

GO:0007612

GO:0007613

GO:0008150

GO:0008283

GO:0008284

GO:0008286

GO:0008544

GO:0008584

GO:0009056

GO:0009058

GO:0009790

GO:0009887

GO:0009897

GO:0010008

GO:0014068

GO:0016020

GO:0016021

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019087

GO:0019904

GO:0022607

GO:0030238

GO:0030325

GO:0030335

GO:0030424

GO:0031017

GO:0031410

GO:0031981

GO:0031994

GO:0031995

GO:0032147

GO:0032148

GO:0032590

GO:0032809

GO:0032869

GO:0032991

GO:0034641

GO:0038024

GO:0038083

GO:0040007

GO:0040011

GO:0042592

GO:0042593

GO:0043167

GO:0043226

GO:0043235

GO:0043243

GO:0043410

GO:0043548

GO:0043559

GO:0043560

GO:0044281

GO:0044403

GO:0044877

GO:0045429

GO:0045725

GO:0045821

GO:0045840

GO:0045893

GO:0045995

GO:0046326

GO:0046777

GO:0048639

GO:0048856

GO:0048870

GO:0050877

GO:0051290

GO:0051425

GO:0051446

GO:0051897

GO:0055085

GO:0060267

GO:0065003

GO:0070062

GO:0071363

GO:0097062

GO:0097242

GO:0140014

GO:1990535

GO:2000194

HGNC:6091

HPA036302

HPA036303

Hs.208334.0.S1_3p_at

Hs.208334.0.S2_3p_s_at

Hs.89695.2.A1_3p_at

Hs.98401.0.S1_3p_at

ILMN_1670918

INSR

INSR-201

INSR-202

IPR000494

IPR000719

IPR001245

IPR002011

IPR003961

IPR006211

IPR006212

IPR008266

IPR009030

IPR011009

IPR013783

IPR016246

IPR017441

IPR020635

IPR036116

IPR036941

IPR040969

J03466

J05043

M0R3E6

M10051

M10051_s_at

M23100

M24555

M27195

M27197

M29929

M29930

M32823

M32824

M32825

M32826

M32827

M32828

M32829

M32830

M32831

M32832

M32833

M32834

M32835

M32836

M32837

M32838

M32839

M32840

M32841

M32842

M32972

M76592

MIM:147670

MIM:246200

MIM:262190

MIM:609968

MIM:610549

NM_000208

NM_001079817

NP_000199

NP_001073285

PF00757

PF01030

PF07714

PF17870

PH_hs_0025683

PR00109

SM00060

SM00219

SM00261

TC19001111.hg

UPI0000140EE6

UPI000020324D

X02160

X02160_at

XM_011527988

XM_011527989

XP_011526290

XP_011526291

Participant Of

hasComponent

Insulin receptor [plasma membrane]

Other forms of this molecule

p-6Y-INSR(763-1382) [endosome membrane]

INSR(763-1382) [endosome membrane]

INSR(28-758) [endosome membrane]

p-6Y-INSR(763-1382) [plasma membrane]

INSR(28-758) [plasma membrane]

Inferred To

INSR(763-1382) [plasma membrane] (Bos taurus)

INSR(763-1382) [plasma membrane] (Canis familiaris)

INSR(763-1382) [plasma membrane] (Danio rerio)

INSR(763-1382) [plasma membrane] (Drosophila melanogaster)

INSR(763-1382) [plasma membrane] (Gallus gallus)

INSR(763-1382) [plasma membrane] (Mus musculus)

INSR(763-1382) [plasma membrane] (Rattus norvegicus)

INSR(763-1382) [plasma membrane] (Sus scrofa)

INSR(763-1382) [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001073285.1, NP_000199.2

ZINC - World Drugs

INSR_HUMAN

OpenTargets

ENSG00000171105

ZINC - FDA approved

INSR_HUMAN

ZINC - Substances

INSR_HUMAN

ZINC target

P06213

ZINC - Biogenic

INSR_HUMAN

PRO

P06213

PDB

4OGA, 2B4S, 1GAG, 5J3H, 6PXW, 2MFR, 1IR3, 5E1S, 3BU6, 3W13, 3W12, 2AUH, 6PXV, 4XLV, 5KQV, 1P14, 1I44, 4ZXB, 3BU3, 2Z8C, 3W11, 4IBM, 1IRK, 3BU5, 3ETA, 1RQQ, 4XST, 6HN4, 4XSS, 6HN5, 3EKN, 5U1M, 2HR7, 3EKK, 5HHW

ZINC - Investigational

INSR_HUMAN

ZINC - Metabolites

INSR_HUMAN

IntEnz

2.7.10.1

GeneCards

P06213

ZINC - Predictions - Purchasable

INSR_HUMAN

Orphanet

16263

HMDB Protein

HMDBP01521

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.979	32
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.799	9
UniProt:P35570 Irs1	7	p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-1168867) phospho-p-6Y-IRS1 [plasma membrane] (R-RNO-2445090) IRS1 [plasma membrane] (R-RNO-2425392) IRS1 [cytosol] (R-RNO-74769) phospho-p-Y-IRS1 [cytosol] (R-RNO-74772) phospho-p-Y-IRS1 [plasma membrane] (R-RNO-198366)	0.791	5
UniProt:P35568 IRS1	5	IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090) IRS1 [cytosol] (R-HSA-74769) p-Y-IRS1 [cytosol] (R-HSA-74772) p-Y-IRS1 [plasma membrane] (R-HSA-198366)	0.704	5
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.688	3
UniProt:Q13322 GRB10	1	GRB10 [cytosol] (R-HSA-110009)	0.581	4
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.573	2
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563)	0.564	2
UniProt:Q9Y4H2 IRS2	4	IRS2 [cytosol] (R-HSA-57528) IRS2 [plasma membrane] (R-HSA-2428927) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.527	4
UniProt:Q99490 AGAP2	1	AGAP2 [cytosol] (R-HSA-622355)	0.524	2
UniProt:Q13257 MAD2L1	2	Activated MAD2L1 [cytosol] (R-HSA-141447) MAD2L1 [cytosol] (R-HSA-141400)	0.463	2