Reactome | p-Y427-SHC1 [cytosol]

p-Y427-SHC1 [cytosol]

Stable Identifier

R-HSA-74684

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SHC transforming protein

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Other interleukin signaling (Homo sapiens)
      - FLT3 Signaling (Homo sapiens)
        
        RAF/MAP kinase cascade (Homo sapiens)
        
        RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Homo sapiens)
        
        p-Y427-SHC1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29353 SHC1

Gene Names

SHC1, SHC, SHCA

Chain

chain:1-583

Reference Genes

BioGPS Gene:6464 SHC1

COSMIC (genes):SHC1 SHC1

CTD Gene:6464 SHC1

dbSNP Gene:6464 SHC1

ENSEMBL:ENSG00000160691 SHC1

ENSEMBL_homo_sapiens_GENE:ENSG00000160691 SHC1

HGNC:10840 SHC1

KEGG Gene (Homo sapiens):6464 SHC1

Monarch:6464 SHC1

NCBI Gene:6464 SHC1

OMIM:600560 SHC1

UCSC:P29353 SHC1

Reference Transcript

Other Identifiers

0003840148

0004480253

0006370025

11727363_a_at

11727364_s_at

11732136_a_at

11758297_s_at

16305

16693898

1844

1MIL

1N3H

1OY2

1QG1

1SHC

1TCE

1WCP

201469_s_at

214853_s_at

2436987

2436988

2436989

2436990

2436991

2436992

2436995

2436996

2436997

2436998

2436999

2437000

2437002

2437003

2437004

2437005

2437006

2437007

2437009

2437010

2437011

2437012

2437013

2437014

2437015

2437016

2437018

2L1C

3759015

3759016

38118_at

4JMH

4XWX

5374

5CZI

6464

6DM4

7920600

A_23_P200443

A_24_P68585

AAB49972

AAH14158

AAH33925

AB451255

AB451379

AK292143

AK315842

AL451085

BAF84832

BAF98733

BAG70069

BAG70193

BC014158

BC033925

CAA48251

CAA70977

CAB005374

CAB016305

CCDS1076

CCDS30881

CCDS44233

CCDS44234

CH471121

EAW53168

EAW53169

EAW53170

EAW53171

ENSG00000160691

ENSP00000357430

ENSP00000357435

ENSP00000357438

ENSP00000401303

ENST00000368445

ENST00000368445.9

ENST00000368450

ENST00000368450.5

ENST00000368453

ENST00000368453.8

ENST00000448116

ENST00000448116.6

EntrezGene:6464

GE59385

GO:0000165

GO:0000187

GO:0001525

GO:0001784

GO:0002376

GO:0003674

GO:0005068

GO:0005154

GO:0005158

GO:0005159

GO:0005168

GO:0005515

GO:0005543

GO:0005575

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0006464

GO:0006950

GO:0007010

GO:0007155

GO:0007165

GO:0007173

GO:0007176

GO:0007265

GO:0007411

GO:0007507

GO:0008284

GO:0008286

GO:0008289

GO:0016032

GO:0019221

GO:0019899

GO:0030674

GO:0030971

GO:0031532

GO:0032991

GO:0035556

GO:0035723

GO:0036498

GO:0038095

GO:0038110

GO:0038128

GO:0040008

GO:0040011

GO:0042127

GO:0042742

GO:0043066

GO:0043167

GO:0043226

GO:0043410

GO:0044403

GO:0045892

GO:0045893

GO:0046579

GO:0046875

GO:0048408

GO:0048646

GO:0048856

GO:0048870

GO:0050900

GO:0070374

GO:0070435

GO:0071363

GO:0098609

HGNC:10840

HPA001844

Hs.81972.0.A1_3p_a_at

Hs.81972.1.A1_3p_a_at

ILMN_1701967

ILMN_1721022

ILMN_1812570

IPR000980

IPR006019

IPR006020

IPR011993

IPR029586

IPR035676

IPR036860

MIM:600560

NM_001130040

NM_001130041

NM_001202859

NM_003029

NM_183001

NP_001123512

NP_001123513

NP_001189788

NP_003020

NP_892113

PF00017

PF00640

PH_hs_0030190

PR00401

PR00629

Q5T181

Q5T182

Q5T187

Q5T188

SHC1

SHC1-202

SHC1-204

SHC1-205

SHC1-210

SM00252

SM00462

TC01006381.hg

U73377

U73377_at

UPI00000726C0

UPI000013EE17

UPI0000149CB2

UPI00002048B4

X68148

X6R6D0

XM_005245449

XM_005245451

XM_011509892

XM_011509893

XM_011509894

XM_011509897

XM_011509898

XM_017002081

XM_017002082

XM_017002083

XM_024449083

XM_024449084

XP_005245506

XP_005245508

XP_011508194

XP_011508195

XP_011508196

XP_011508199

XP_011508200

XP_016857570

XP_016857571

XP_016857572

XP_024304851

XP_024304852

Y09847

Participant Of

output

hasComponent

input

Other forms of this molecule

SHC1 [cytosol]

p-Y349,Y350-SHC1 [cytosol]

p-Y349,Y350,Y427-SHC1 [cytosol]

p-Y-SHC1 [cytosol]

Inferred To

Ghost homologue of p-Y427-SHC1 [cytosol] (Caenorhabditis elegans)

phospho-p-Y427-SHC1 [cytosol] (Bos taurus)

phospho-p-Y427-SHC1 [cytosol] (Canis familiaris)

phospho-p-Y427-SHC1 [cytosol] (Danio rerio)

phospho-p-Y427-SHC1 [cytosol] (Drosophila melanogaster)

phospho-p-Y427-SHC1 [cytosol] (Gallus gallus)

phospho-p-Y427-SHC1 [cytosol] (Mus musculus)

phospho-p-Y427-SHC1 [cytosol] (Rattus norvegicus)

phospho-p-Y427-SHC1 [cytosol] (Sus scrofa)

phospho-p-Y427-SHC1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 427

Coordinate

427

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001189788.1, NP_892113.4, NP_001123513.1, NP_001123512.1, NP_003020.2

OpenTargets

ENSG00000160691

ZINC - Substances

SHC1_HUMAN

GeneCards

P29353

ZINC target

P29353

PRO

P29353

ZINC - Predictions - Purchasable

SHC1_HUMAN

PDB

6DM4, 5CZI, 1TCE, 4JMH, 4XWX, 2L1C, 1MIL, 1OY2, 1WCP, 1QG1, 1N3H, 1SHC

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.968	35
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.968	26
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.829	6
UniProt:P62994 Grb2	3	GRB2-1 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-55929) GRB2-1 [cytosol] (R-RNO-74686)	0.822	5
UniProt:P22681 CBL	6	p-Y371-CBL [cytosol] (R-HSA-182940) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [plasma membrane] (R-HSA-182923) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.77	5
UniProt:P04626 ERBB2	12	p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.702	14
UniProt:P21860 ERBB3			0.702	6
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.659	4
UniProt:Q15303 ERBB4			0.609	6
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.589	6
UniProt:P06213 INSR	6	INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.573	2
UniProt:P35968 KDR	2	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382)	0.564	2
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.564	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.564	3
UniProt:P16573	9	CEACAM3 [specific granule membrane] (R-RNO-6806076-4) CEACAM1 [tertiary granule membrane] (R-RNO-6800953-4) CEACAM1 [specific granule membrane] (R-RNO-6799528-4) CEACAM3 [plasma membrane] (R-RNO-197706-4) CEACAM1 [plasma membrane] (R-RNO-197701-4) PSG3 [extracellular region] (R-RNO-8870747-4) PSG1 [extracellular region] (R-RNO-8870766-4) PSG8 [extracellular region] (R-RNO-8870757-4) PSG6 [extracellular region] (R-RNO-8870759-4)	0.544	3
UniProt:P33151 CDH5	2	VE-cadherin [plasma membrane] (R-HSA-418992) p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435)	0.544	2
UniProt:Q9UQC2 GAB2	4	p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-5Y-GAB2 [cytosol] (R-HSA-8855574) GAB2 [cytosol] (R-HSA-508239) p-Y-GAB2 [cytosol] (R-HSA-912529)	0.544	2
UniProt:P26954 IL3B2			0.544	4
UniProt:O95782 AP2A1	5	AP2A1 [endocytic vesicle membrane] (R-HSA-416641) AP2A1 [endolysosome membrane] (R-HSA-6784829) AP2A1 [plasma membrane] (R-HSA-177494) AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449) AP2A1 [cytosol] (R-HSA-182143)	0.527	3
UniProt:O94973 AP2A2	6	AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [plasma membrane] (R-HSA-177502) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155)	0.527	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [endolysosome membrane] (R-HSA-6784828) AP2M1 [lysosomal membrane] (R-HSA-196144) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.527	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	2
UniProt:P32927 CSF2RB	6	CSF2RB [plasma membrane] (R-HSA-879960) p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.527	4
UniProt:Q8TF42 UBS3B			0.527	3
UniProt:P03495 NS1			0.508	2
UniProt:Q16832 DDR2	1	DDR2 [plasma membrane] (R-HSA-211419)	0.508	2
UniProt:Q02763 TEK	2	p-5Y,S1119-TEK [plasma membrane] (R-HSA-204772) TEK [plasma membrane] (R-HSA-197755)	0.462	2
UniProt:P04629 NTRK1	4	NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.462	2
UniProt:A9UF07 A9UF07			0.462	4
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.462	3