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What is Reactome ?
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p-Y427-SHC1 [cytosol]
Stable Identifier
R-HSA-74684
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHC transforming protein
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
Dissociation of p-Y427-SHC1 from insulin receptor (Homo sapiens)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
GRB2-1:SOS1 binds p-Y427-SHC1 (Homo sapiens)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
Phosphorylation of SHC1 (Homo sapiens)
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
Signal attenuation (Homo sapiens)
De-phosphorylation of p-Y427-SHC1 (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Homo sapiens)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Homo sapiens)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Homo sapiens)
p-Y427-SHC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29353 SHC1
Gene Names
SHC1, SHC, SHCA
Chain
chain:1-583
Reference Genes
BioGPS Gene:6464 SHC1
COSMIC (genes):SHC1 SHC1
CTD Gene:6464 SHC1
dbSNP Gene:6464 SHC1
ENSEMBL:ENSG00000160691 SHC1
HGNC:10840 SHC1
KEGG Gene (Homo sapiens):6464 SHC1
Monarch:6464 SHC1
NCBI Gene:6464 SHC1
OMIM:600560 SHC1
UCSC:P29353 SHC1
Reference Transcript
RefSeq:NM_001202859.1 SHC1
RefSeq:NM_001130040.1 SHC1
RefSeq:NM_183001.4 SHC1
RefSeq:NM_001130041.1 SHC1
RefSeq:NM_003029.4 SHC1
Other Identifiers
0003840148
0004480253
0006370025
11727363_a_at
11727364_s_at
11732136_a_at
11758297_s_at
16305
16693891
16693898
1844
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
1WCP
201469_s_at
214853_s_at
2436980
2436981
2436982
2436983
2436984
2436986
2436987
2436988
2436989
2436990
2436991
2436992
2436995
2436996
2436997
2436998
2436999
2437000
2437002
2437003
2437004
2437005
2437006
2437007
2437009
2437010
2437011
2437012
2437013
2437014
2437015
2437016
2437018
2L1C
3759015
3759016
38118_at
4JMH
4XWX
5374
5CZI
6464
6DM4
7920600
A_23_P200443
A_24_P68585
AAB49972
AAH14158
AAH33925
AB451255
AB451379
AK292143
AK315842
AL451085
BAF84832
BAF98733
BAG70069
BAG70193
BC014158
BC033925
CAA48251
CAA70977
CAB005374
CAB016305
CCDS1076
CCDS30881
CCDS44233
CCDS44234
CH471121
EAW53168
EAW53169
EAW53170
EAW53171
ENSG00000160691
ENSP00000357430
ENSP00000357435
ENSP00000357438
ENSP00000401303
ENST00000368445
ENST00000368445.9
ENST00000368450
ENST00000368450.5
ENST00000368453
ENST00000368453.8
ENST00000448116
ENST00000448116.6
EntrezGene:6464
EntrezGene:SHC1
GE59385
GO:0000165
GO:0000187
GO:0000902
GO:0001525
GO:0001784
GO:0002376
GO:0003674
GO:0005068
GO:0005154
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005543
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0005886
GO:0006464
GO:0006950
GO:0007010
GO:0007155
GO:0007165
GO:0007173
GO:0007176
GO:0007265
GO:0007411
GO:0007507
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008286
GO:0008289
GO:0009058
GO:0016032
GO:0019221
GO:0019899
GO:0019901
GO:0030154
GO:0030674
GO:0030971
GO:0031532
GO:0032991
GO:0034641
GO:0035556
GO:0035723
GO:0036498
GO:0038095
GO:0038110
GO:0038128
GO:0040007
GO:0040008
GO:0040011
GO:0042127
GO:0042742
GO:0043066
GO:0043167
GO:0043226
GO:0043410
GO:0044403
GO:0045892
GO:0045893
GO:0046579
GO:0046875
GO:0048408
GO:0048646
GO:0048856
GO:0048870
GO:0050900
GO:0070374
GO:0070435
GO:0071363
GO:0098609
HGNC:10840
HPA001844
Hs.81972.0.A1_3p_a_at
Hs.81972.1.A1_3p_a_at
ILMN_1701967
ILMN_1721022
ILMN_1812570
IPR000980
IPR006019
IPR006020
IPR011993
IPR029586
IPR035676
IPR036860
MIM:600560
NM_001130040
NM_001130041
NM_001202859
NM_003029
NM_183001
NP_001123512
NP_001123513
NP_001189788
NP_003020
NP_892113
PF00017
PF00640
PH_hs_0030190
PR00401
PR00629
Q5T181
Q5T182
Q5T187
Q5T188
SHC1
SHC1-202
SHC1-204
SHC1-205
SHC1-210
SM00252
SM00462
TC01006381.hg
U73377
U73377_at
UPI00000726C0
UPI000013EE17
UPI0000149CB2
UPI00002048B4
X68148
X6R6D0
XM_005245449
XM_005245451
XM_011509892
XM_011509893
XM_011509894
XM_011509897
XM_011509898
XM_017002081
XM_017002082
XM_017002083
XM_024449083
XM_024449084
XP_005245506
XP_005245508
XP_011508194
XP_011508195
XP_011508196
XP_011508199
XP_011508200
XP_016857570
XP_016857571
XP_016857572
XP_024304851
XP_024304852
Y09847
Participant Of
output
Dissociation of p-Y427-SHC1 from insulin receptor
GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates
SHC1 dissociates from integrin alphaIIb beta3
hasComponent
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol]
GRB2-1:SOS1:p-Y427-SHC1 [cytosol]
Insulin:p-6Y-Insulin receptor:p-Y427-SHC1 [plasma membrane]
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane]
input
De-phosphorylation of p-Y427-SHC1
GRB2-1:SOS1 binds p-Y427-SHC1
Other forms of this molecule
SHC1 [cytosol]
p-Y349,Y350-SHC1 [cytosol]
p-Y349,Y350,Y427-SHC1 [cytosol]
p-Y-SHC1 [cytosol]
Inferred To
Ghost homologue of p-Y427-SHC1 [cytosol] (Caenorhabditis elegans)
phospho-p-Y427-SHC1 [cytosol] (Bos taurus)
phospho-p-Y427-SHC1 [cytosol] (Canis familiaris)
phospho-p-Y427-SHC1 [cytosol] (Danio rerio)
phospho-p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
phospho-p-Y427-SHC1 [cytosol] (Gallus gallus)
phospho-p-Y427-SHC1 [cytosol] (Mus musculus)
phospho-p-Y427-SHC1 [cytosol] (Rattus norvegicus)
phospho-p-Y427-SHC1 [cytosol] (Sus scrofa)
phospho-p-Y427-SHC1 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 427
Coordinate
427
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_003020.2
,
NP_001123513.1
,
NP_001123512.1
,
NP_001189788.1
,
NP_892113.4
OpenTargets
ENSG00000160691
GeneCards
P29353
ZINC - Substances
SHC1_HUMAN
ZINC target
P29353
PRO
P29353
ZINC - Predictions - Purchasable
SHC1_HUMAN
PDB
5CZI
,
1TCE
,
2L1C
,
4XWX
,
4JMH
,
1OY2
,
1WCP
,
1N3H
,
1QG1
,
6DM4
,
1SHC
,
1MIL
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.97
37
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.968
26
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
0.829
6
UniProt:P62994 Grb2
3
GRB2-1 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-55929)
GRB2-1 [cytosol]
(R-RNO-74686)
0.822
5
UniProt:P04626 ERBB2
91
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665656)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
p-Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 L755W [plasma membrane]
(R-HSA-9654193)
p-Y-ERBB2 T733I [plasma membrane]
(R-HSA-9654610)
p-Y-ERBB2 H878R [plasma membrane]
(R-HSA-9654835)
p-Y-ERBB2 L869R [plasma membrane]
(R-HSA-9654730)
p-Y-ERBB2 G776S [plasma membrane]
(R-HSA-9664608)
p-Y-ERBB2 L869Q [plasma membrane]
(R-HSA-9654732)
p-Y-ERBB2 G776L [plasma membrane]
(R-HSA-9664600)
p-Y-ERBB2 G776V [plasma membrane]
(R-HSA-9664602)
p-Y-ERBB2 G776C [plasma membrane]
(R-HSA-9664611)
ERBB2 D769Y [plasma membrane]
(R-HSA-9646620)
ERBB2 L755P [plasma membrane]
(R-HSA-9646494)
ERBB2 V842I [plasma membrane]
(R-HSA-9646703)
ERBB2 H878Y [plasma membrane]
(R-HSA-9646824)
ERBB2 T798M [plasma membrane]
(R-HSA-9646825)
ERBB2 D769H [plasma membrane]
(R-HSA-9646617)
ERBB2 T862A [plasma membrane]
(R-HSA-9649434)
ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665621)
ERBB2 L755S [plasma membrane]
(R-HSA-9646423)
ERBB2 I767M [plasma membrane]
(R-HSA-9646737)
ERBB2 V777L [plasma membrane]
(R-HSA-9646579)
ERBB2 D769N [plasma membrane]
(R-HSA-9646636)
ERBB2 T733I [plasma membrane]
(R-HSA-9646765)
ERBB2 V777M [plasma membrane]
(R-HSA-9646591)
ERBB2 V777E [plasma membrane]
(R-HSA-9646586)
ERBB2 L755W [plasma membrane]
(R-HSA-9646516)
ERBB2 L755M [plasma membrane]
(R-HSA-9646517)
ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665622)
ERBB2 H878R [plasma membrane]
(R-HSA-9646822)
ERBB2 V842E [plasma membrane]
(R-HSA-9646710)
ERBB2 T798I [plasma membrane]
(R-HSA-9646823)
ERBB2 R896C [plasma membrane]
(R-HSA-9646714)
ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9646667)
ERBB2 R896H [plasma membrane]
(R-HSA-9646728)
ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665625)
ERBB2 G776S [plasma membrane]
(R-HSA-9664463)
ERBB2 L869R [plasma membrane]
(R-HSA-9646827)
ERBB2 L869Q [plasma membrane]
(R-HSA-9646828)
ERBB2 G776C [plasma membrane]
(R-HSA-9664457)
ERBB2 G776L [plasma membrane]
(R-HSA-9664454)
ERBB2 G776V [plasma membrane]
(R-HSA-9664450)
p-6Y-ERBB2 V777L [plasma membrane]
(R-HSA-9647214)
p-6Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9647215)
ERBB2 L755_T759del [plasma membrane]
(R-HSA-9663599)
p-6Y-ERBB2 R896C [plasma membrane]
(R-HSA-9647208)
p-6Y-ERBB2 V842I [plasma membrane]
(R-HSA-9647209)
p-6Y-ERBB2 I767M [plasma membrane]
(R-HSA-9647211)
p-6Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654692)
p-6Y-ERBB2 D769H [plasma membrane]
(R-HSA-9647200)
p-6Y-ERBB2 T798I [plasma membrane]
(R-HSA-9647202)
p-6Y-ERBB2 L755P [plasma membrane]
(R-HSA-9647196)
p-6Y-ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9647198)
p-6Y-ERBB2 L755S [plasma membrane]
(R-HSA-9647216)
p-6Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665650)
p-6Y-ERBB2 T798M [plasma membrane]
(R-HSA-9647218)
p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665644)
p-6Y-ERBB2 D769Y [plasma membrane]
(R-HSA-9647199)
p-6Y-ERBB2 V777E [plasma membrane]
(R-HSA-9647210)
p-6Y-ERBB2 T733I [plasma membrane]
(R-HSA-9647195)
p-6Y-ERBB2 L755M [plasma membrane]
(R-HSA-9647204)
p-6Y-ERBB2 V777M [plasma membrane]
(R-HSA-9647205)
p-6Y-ERBB2 V842E [plasma membrane]
(R-HSA-9647206)
p-6Y-ERBB2 D769N [plasma membrane]
(R-HSA-9647207)
p-6Y-ERBB2 R896H [plasma membrane]
(R-HSA-9647217)
p-6Y-ERBB2 L755W [plasma membrane]
(R-HSA-9647201)
p-6Y-ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665634)
p-6Y-ERBB2 H878R [plasma membrane]
(R-HSA-9647203)
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863841)
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863836)
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864084)
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864090)
ERBB2 [plasma membrane]
(R-HSA-372889)
p-Y877-ERBB2 [plasma membrane]
(R-HSA-1810438)
p-6Y-ERBB2 [plasma membrane]
(R-HSA-1963569)
p-6Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864081)
p-Y-ERBB2 [plasma membrane]
(R-HSA-1678589)
p-Y,Y877-ERBB2 [plasma membrane]
(R-HSA-1810446)
p-7Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864079)
p-7Y-ERBB2 [plasma membrane]
(R-HSA-1248698)
0.772
15
UniProt:P22681 CBL
6
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
p-Y-CBL [cytosol]
(R-HSA-8875457)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
0.77
5
UniProt:P21860 ERBB3
0.702
6
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.659
4
UniProt:Q15303 ERBB4
0.609
6
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.589
6
UniProt:P06213 INSR
6
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.573
2
UniProt:P35968 KDR
2
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
0.564
2
UniProt:Q07889 SOS1
3
SOS1 [plasma membrane]
(R-HSA-983559)
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [cytosol]
(R-HSA-64847)
0.564
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.564
3
UniProt:Q13137 CACO2
0.553
3
UniProt:P16573
9
CEACAM3 [specific granule membrane]
(R-RNO-6806076-4)
CEACAM1 [tertiary granule membrane]
(R-RNO-6800953-4)
CEACAM1 [specific granule membrane]
(R-RNO-6799528-4)
CEACAM3 [plasma membrane]
(R-RNO-197706-4)
CEACAM1 [plasma membrane]
(R-RNO-197701-4)
PSG3 [extracellular region]
(R-RNO-8870747-4)
PSG1 [extracellular region]
(R-RNO-8870766-4)
PSG8 [extracellular region]
(R-RNO-8870757-4)
PSG6 [extracellular region]
(R-RNO-8870759-4)
0.544
3
UniProt:P33151 CDH5
2
VE-cadherin [plasma membrane]
(R-HSA-418992)
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
0.544
2
UniProt:Q9UQC2 GAB2
4
GAB2 [cytosol]
(R-HSA-508239)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
p-Y-GAB2 [cytosol]
(R-HSA-912529)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
0.544
2
UniProt:P26954 IL3B2
0.544
4
UniProt:O95782 AP2A1
5
AP2A1 [plasma membrane]
(R-HSA-177494)
AP2A1 [endolysosome membrane]
(R-HSA-6784829)
AP2A1 [endocytic vesicle membrane]
(R-HSA-416641)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138449)
AP2A1 [cytosol]
(R-HSA-182143)
0.527
3
UniProt:O94973 AP2A2
6
AP2A2(1-939) [secretory granule membrane]
(R-HSA-6800412)
AP2A2(1-939) [endolysosome membrane]
(R-HSA-6784819)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-HSA-6800414)
AP2A2(1-939) [plasma membrane]
(R-HSA-177502)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138448)
AP2A2(1-939) [cytosol]
(R-HSA-182155)
0.527
2
UniProt:Q96CW1 AP2M1
6
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.527
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
UniProt:P32927 CSF2RB
6
CSF2RB [plasma membrane]
(R-HSA-879960)
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
0.527
4
UniProt:Q8TF42 UBS3B
0.527
3
UniProt:P03495 NS1
0.508
2
UniProt:Q16832 DDR2
1
DDR2 [plasma membrane]
(R-HSA-211419)
0.508
2
UniProt:A9UF07 A9UF07
0.462
4
UniProt:Q12774 ARHGEF5
1
ARHGEF5 [cytosol]
(R-HSA-8873909)
0.462
3
UniProt:Q02763 TEK
2
p-5Y,S1119-TEK [plasma membrane]
(R-HSA-204772)
TEK [plasma membrane]
(R-HSA-197755)
0.462
2
UniProt:P04629 NTRK1
4
NTRK1 [Golgi membrane]
(R-HSA-3008805)
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.462
2
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