Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PI3K [cytosol]
Stable Identifier
R-HSA-74693
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
p85 associates with both p-Nephrin and CD2AP (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K:CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K bound to TRAT [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K bound to TRAT [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
NPM1-ALK- and PI3K-dependent MDM2 phosphorylation (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer:PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by KIT in disease (Homo sapiens)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by LTK in cancer (Homo sapiens)
CLIP1-LTK fusion binds PI3K to activate AKT (Homo sapiens)
CLIP1(1-1083)-p-6Y LTK(488-864) fusion dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by PDGFR in disease (Homo sapiens)
Signaling by PDGFRA extracellular domain mutants (Homo sapiens)
PI3-kinase binds to PDGFRA extracellular domain dimers (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-11Y PDGFRA extracellular domain dimers:PI3K [endoplasmic reticulum membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-11Y PDGFRA extracellular domain dimers:PI3K [endoplasmic reticulum membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)
PI3-kinase binds to mutant PDGFR receptor (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-11Y PDGFR mutant dimers:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-11Y PDGFR mutant dimers:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Tie2 Signaling (Homo sapiens)
Interaction of Tie2 and p85 of PI3K (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p85 bound to Tie2 [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K bound to TRAT [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Recruitment of PI3K to plasma membrane (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K bound to TRAT [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
PI3K associates with phosphorylated GAB2 (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Phosphorylation of PIP2 to PIP3 by PI3K (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
PI3K binds to p-6Y-SYK (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K:p-6Y-SYK [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K:p-6Y-SYK [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K bound to TRAT [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K bound to TRAT [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS:GTP binds PI3K (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p21 RAS:GTP:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
Active ALK recruits PI3K (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by LTK (Homo sapiens)
Active LTK receptor binds PI3K (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
PI3-kinase binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-6Y-VEGFR2 binds PI3K (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
p-AXL binds PI3K (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Homo sapiens)
PI3K [cytosol] (Homo sapiens)
Participants
components
PI3K-catalytic subunit [cytosol]
(Homo sapiens)
PI3K-regulatory subunit [cytosol]
(Homo sapiens)
Participates
as a component of
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer:PI3K [cytosol] (Homo sapiens)
Active ALK:PI3K [plasma membrane] (Homo sapiens)
p-11Y PDGFRA extracellular domain dimers:PI3K [endoplasmic reticulum membrane] (Homo sapiens)
p-11Y PDGFR mutant dimers:PI3K [plasma membrane] (Homo sapiens)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Homo sapiens)
CLIP1(1-1083)-p-6Y LTK(488-864) fusion dimer:PI3K [plasma membrane] (Homo sapiens)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PI3K bound to TRAT [plasma membrane] (Homo sapiens)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
PI3K:p-6Y-SYK [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Homo sapiens)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Homo sapiens)
p21 RAS:GTP:PI3K [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Homo sapiens)
p85 bound to Tie2 [plasma membrane] (Homo sapiens)
PI3K:CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
as an input of
Active ALK recruits PI3K (Homo sapiens)
PI3-kinase binds to PDGFRA extracellular domain dimers (Homo sapiens)
PI3-kinase binds to mutant PDGFR receptor (Homo sapiens)
Active LTK receptor binds PI3K (Homo sapiens)
Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)
PI3K binds to p-6Y-SYK (Homo sapiens)
PI3-kinase binds to the active receptor (Homo sapiens)
Recruitment of PI3K to plasma membrane (Homo sapiens)
p-AXL binds PI3K (Homo sapiens)
p-6Y-VEGFR2 binds PI3K (Homo sapiens)
PI3K associates with phosphorylated GAB2 (Homo sapiens)
RAS:GTP binds PI3K (Homo sapiens)
p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Homo sapiens)
Interaction of Tie2 and p85 of PI3K (Homo sapiens)
p85 associates with both p-Nephrin and CD2AP (Homo sapiens)
CLIP1-LTK fusion binds PI3K to activate AKT (Homo sapiens)
Inferred To
PI3K [cytosol]
(Bos taurus)
PI3K [cytosol]
(Caenorhabditis elegans)
PI3K [cytosol]
(Canis familiaris)
PI3K [cytosol]
(Danio rerio)
PI3K [cytosol]
(Drosophila melanogaster)
PI3K [cytosol]
(Gallus gallus)
PI3K [cytosol]
(Mus musculus)
PI3K [cytosol]
(Rattus norvegicus)
PI3K [cytosol]
(Sus scrofa)
PI3K [cytosol]
(Xenopus tropicalis)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
