Insulin degradation

Stable Identifier
R-HSA-74730
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'insulin' is present.

This reaction takes place in the 'endosome' and is mediated by the 'insulysin activity of IDA (insulin degrading activity' of 'IDA (insulin degrading activity)'.

Literature References
PubMed ID Title Journal Year
3061785 Insulin degradation: mechanisms, products, and significance.

Duckworth, WC

Endocr Rev 1989
9793760 Insulin degradation: progress and potential.

Duckworth, WC, Bennett, RG, Hamel, FG

Endocr Rev 1998
8682206 Endosomal proteolysis of internalized proteins.

Authier, F, Posner, BI, Bergeron, JJ

FEBS Lett 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of IDA [endosome lumen]
Physical Entity
Activity
Created