Re-integration of insulin receptor into plasma membrane

Stable Identifier
R-HSA-74734
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The endosome fuses with the plasma membrane allowing the insulin receptor to re-integrate there. Any degraded insulin remnants which remained in the endosome are also expelled (The majority having been excreted into the cytoplasm and secreted out of the cell via other mechanisms).

The cycle is complete with the dephosphorylated receptor now back in the plasma membrane available to bind the next insulin molecule presented to it. There is some insulin receptor degradation over time when damaged insulin receptors are not recycled but fuse instead with the lysosomes where they are degraded. However the majority of insulin receptors are recycled back to the plasma membrane with greater than 95% efficiency.

Literature References
PubMed ID Title Journal Year
2986535 Uptake of insulin and other ligands into receptor-rich endocytic components of target cells: the endosomal apparatus.

Bergeron, JJ, Cruz, J, Khan, MN, Posner, BI

Annu Rev Physiol 1985
Participants
Participant Of
Orthologous Events
Authored
Created