De-phosphorylation of p-Y427-SHC1

Stable Identifier
R-HSA-74748
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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At the beginning of this reaction, 1 molecule of 'phospho-SHC' is present. At the end of this reaction, 1 molecule of 'Orthophosphate', and 1 molecule of 'SHC transforming protein' are present.

This reaction takes place in the 'cytosol' and is mediated by the 'protein tyrosine phosphatase activity' of 'protein tyrosine phosphatase' (Sasaoka et al. 1996).
This is a black box event since the event of dephosphorylation is inferred from other reaction where this process occurs after other stimulation (Gu et al. 1999).

Literature References
PubMed ID Title Journal Year
8702728 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner

Sasaoka, T, Ishihara, H, Sawa, T, Ishiki, M, Morioka, H, Imamura, T, Usui, I, Takata, Y, Kobayashi, M

J. Biol. Chem. 1996
21884975 Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding

Kleiman, LB, Maiwald, T, Conzelmann, H, Lauffenburger, DA, Sorger, PK

Mol. Cell 2011
10427092 Shc and FAK differentially regulate cell motility and directionality modulated by PTEN

Gu, J, Tamura, M, Pankov, R, Danen, EH, Takino, T, Matsumoto, K, Yamada, KM

J. Cell Biol. 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of protein tyrosine phosphatase [cytosol]
Physical Entity
Activity
Created