PIK3CA [cytosol]

Stable Identifier
R-HSA-74787
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PI3K-p110, PI3-kinase p110 subunit alpha, Phosphatidylinositol 3-kinase catalytic subunit, alpha isoform (EC 2.7.1.137) (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K), Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PtdIns- 3-kinase p110
Icon
PIK3CA [cytosol] icon
PIK3CA [cytosol] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P42336 PIK3CA
Gene Names
PIK3CA
Chain
chain:1-1068
Reference Genes
BioGPS Gene:5290 PIK3CA
COSMIC (genes):PIK3CA PIK3CA
CTD Gene:5290 PIK3CA
dbSNP Gene:5290 PIK3CA
ENSEMBL:ENSG00000121879 PIK3CA
HGNC:8975 PIK3CA
KEGG:hsa:5290 PIK3CA
Monarch:5290 PIK3CA
NCBI Gene:5290 PIK3CA
OMIM:171834 PIK3CA
UCSC:P42336 PIK3CA
Reference Transcript
Other Identifiers
11745214_a_at
11763283_at
16948209
17122920
17122922
204369_PM_at
204369_at
231854_PM_at
231854_at
235980_PM_at
235980_at
2653841
2653852
2653853
2653854
2653855
2653856
2653857
2653858
2653860
2653861
2653862
2653864
2653865
2653866
2653867
2653868
2653869
2653871
2653872
2653873
2653874
2653875
2653876
2653877
2653879
2653880
2653881
2653882
2653883
2653884
2653885
2653890
3935882
3935885
3935887
3935889
3935891
3935893
3935895
3935897
40704_at
41969_at
5290
55954_at
8084016
81516_at
81657_at
83177_at
90039_at
A_14_P113684
A_14_P127878
A_14_P128410
A_21_P0012238
A_23_P92057
GE60386
GE88555
GO:0001525
GO:0001889
GO:0001932
GO:0001944
GO:0002376
GO:0003012
GO:0003824
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005942
GO:0005943
GO:0005944
GO:0005975
GO:0006006
GO:0006325
GO:0006629
GO:0006909
GO:0007010
GO:0007173
GO:0008286
GO:0010468
GO:0010592
GO:0010629
GO:0012501
GO:0014704
GO:0014823
GO:0014870
GO:0016192
GO:0016242
GO:0016301
GO:0016303
GO:0016310
GO:0016740
GO:0030027
GO:0030036
GO:0030168
GO:0030295
GO:0030835
GO:0031295
GO:0032008
GO:0032869
GO:0035005
GO:0035994
GO:0036092
GO:0038084
GO:0040014
GO:0043201
GO:0043276
GO:0043457
GO:0043491
GO:0043524
GO:0043542
GO:0043560
GO:0046854
GO:0046934
GO:0048009
GO:0048015
GO:0048471
GO:0048661
GO:0048856
GO:0048870
GO:0050852
GO:0051897
GO:0055119
GO:0060048
GO:0060612
GO:0071333
GO:0071464
GO:0071548
GO:0086003
GO:0097009
GO:0098772
GO:0106310
GO:0110053
GO:0140096
GO:0141068
GO:1903544
GO:1905477
GO:2000270
GO:2000811
HMNXSV003040760
Hs.120905.0.S1_3p_at
Hs.122419.0.S1_3p_at
ILMN_1705396
ILMN_1705468
PH_hs_0031379
TC03000951.hg
TC03002674.hg
TC22000929.hg
Z29090_at
g5453891_3p_at
p28442
Participates
as a component of
as an input of
as a member of
Other forms of this molecule
PIK3CA H1047L [cytosol]
PIK3CA H1047R [cytosol]
PIK3CA R38C [cytosol]
PIK3CA R38G [cytosol]
PIK3CA R38S [cytosol]
PIK3CA R38H [cytosol]
PIK3CA E542Q [cytosol]
PIK3CA Q546P [cytosol]
PIK3CA Q546R [cytosol]
PIK3CA Q546H [cytosol]
PIK3CA E545G [cytosol]
PIK3CA Q546L [cytosol]
PIK3CA E542V [cytosol]
PIK3CA E545V [cytosol]
PIK3CA Q546E [cytosol]
PIK3CA E545Q [cytosol]
PIK3CA E545K [cytosol]
PIK3CA E545A [cytosol]
PIK3CA Q546K [cytosol]
PIK3CA E542K [cytosol]
PIK3CA H1047Y [cytosol]
PIK3CA M1043V [cytosol]
PIK3CA M1043T [cytosol]
PIK3CA M1043I [cytosol]
Inferred To
Pik3ca [cytosol] (Mus musculus)
Pik3ca [cytosol] (Rattus norvegicus)
age-1 [cytosol] (Caenorhabditis elegans)
pikB [cytosol] (Dictyostelium discoideum)
pikG [cytosol] (Dictyostelium discoideum)
Ghost homologue of PIK3CA [cytosol] (Drosophila melanogaster)
Homologues of PIK3CA [cytosol] (Dictyostelium discoideum)
pikF [cytosol] (Dictyostelium discoideum)
pikC [cytosol] (Dictyostelium discoideum)
pikA [cytosol] (Dictyostelium discoideum)
pikH [cytosol] (Dictyostelium discoideum)
pik3ca [cytosol] (Danio rerio)
pik3ca [cytosol] (Xenopus tropicalis)
PIK3CA [cytosol] (Bos taurus)
PIK3CA [cytosol] (Canis familiaris)
PIK3CA [cytosol] (Gallus gallus)
PIK3CA [cytosol] (Sus scrofa)
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
IntEnz
HPA
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (22)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P27986 PIK3R1  16 0.967 64
 UniProt:O00459 PIK3R2  3 0.899 49
 UniProt:Q92569 PIK3R3  2 0.883 47
 UniProt:P35568 IRS1  5 0.853 42
 UniProt:P62993 GRB2  1 0.8 6
 UniProt:P21860 ERBB3      0.723 18
 UniProt:P27986-2 PIK3R1      0.556 3
 UniProt:P54253 ATX1      0.556 3
 UniProt:P42858 HTT  1 0.556 3
 UniProt:P01100 FOS  2 0.556 3
 UniProt:P54252 ATXN3  2 0.556 3
 UniProt:Q6ZMZ0 RNF19B  1 0.527 2
 UniProt:Q8WTX9 ZDHC1      0.527 2
 UniProt:Q9NZU1 FLRT1  1 0.527 2
 UniProt:Q01523 DEFA5  5 0.527 2
 UniProt:Q9H8J5 MANS1      0.527 2
 UniProt:Q8TDQ0 HAVCR2  1 0.527 2
 UniProt:Q15365 PCBP1  1 0.527 2
 UniProt:Q9UHF4 IL20RA  1 0.527 2
 UniProt:Q9UH99 SUN2  1 0.527 2
 UniProt:P03496 NS  2 0.527 7
 UniProt:P42336 PIK3CA  20 0.462 3
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