atROL binds RBP1 to form RBP1:atROL

Stable Identifier
R-HSA-74843
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Before esterification, retinol binds to RBP1 in RPE
ReviewStatus
5/5
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atROL binds RBP1 to form RBP1:atROL
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Once all-trans-retinol (atROL) enters the retinal pigment epithelium (RPE) and before esterification takes place, atROL binds to cellular retinol-binding protein 1 (RBP1) (Folli et al. 2001). The resultant complex (RBP1:atROL) serves as a substrate for lecithin retinol acyltransferase (LRAT), the main enzyme responsible for the esterification of atROL.
Literature References
PubMed ID Title Journal Year
11274389 Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein

Folli, C, Berni, R, Bolchi, A, Calderone, V, Stoppini, M, Zanotti, G, Ottonello, S

Proc. Natl. Acad. Sci. U.S.A. 2001
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Orthologous Events
atROL binds RBP1 to form RBP1:atROL (Bos taurus)
atROL binds RBP1 to form RBP1:atROL (Caenorhabditis elegans)
atROL binds RBP1 to form RBP1:atROL (Canis familiaris)
atROL binds RBP1 to form RBP1:atROL (Danio rerio)
atROL binds RBP1 to form RBP1:atROL (Drosophila melanogaster)
atROL binds RBP1 to form RBP1:atROL (Gallus gallus)
atROL binds RBP1 to form RBP1:atROL (Mus musculus)
atROL binds RBP1 to form RBP1:atROL (Rattus norvegicus)
atROL binds RBP1 to form RBP1:atROL (Sus scrofa)
atROL binds RBP1 to form RBP1:atROL (Xenopus tropicalis)
Authored
Jassal, B  (2012-08-17)
Carleton, KL  (2003-07-31)
Reviewed
Blaner, WS  (2013-01-31)
Created
Carleton, KL  (2003-07-31)
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