RDH10,11 oxidise 11cROL to 11cRAL

Stable Identifier
R-HSA-74872
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
RDHs oxidise 11-cis-retinol to 11-cis-retinal
ReviewStatus
5/5
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Using NADP+ as cofactor, several members of the short-chain dehydrogenases/reductases (SDR) family can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells. Retinol dehydrogenases 10 and 11 (RDH10 and 11) are two such members utilizing the cofactor NADP+ (Wu et al. 2002, Kedishvili et al. 2002 respectively). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.
Literature References
PubMed ID Title Journal Year
12407145 Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE

Rohrer, B, Wu, BX, Ma, JX, Fan, J, Chen, Y, Chen, Y, Crouch, RK

Invest. Ophthalmol. Vis. Sci. 2002
12036956 Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)

Belyaeva, OV, Lin, DW, Nelson, PS, Chumakova, OV, Chetyrkin, SV, Matsumura, M, Lapshina, EA, Kedishvili, NY

J. Biol. Chem. 2002
Participants
Participates
Catalyst Activity

NADP-retinol dehydrogenase activity of RDH10,11 [endoplasmic reticulum membrane]

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