RDH10,11 oxidise 11cROL to 11cRAL

Stable Identifier
R-HSA-74872
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
RDHs oxidise 11-cis-retinol to 11-cis-retinal
Locations in the PathwayBrowser
Summation

Using NADP+ as cofactor, several members of the short-chain dehydrogenases/reductases (SDR) family can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells. Retinol dehydrogenases 10 and 11 (RDH10 and 11) are two such members utilizing the cofactor NADP+ (Wu et al. 2002, Kedishvili et al. 2002 respectively). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.

Literature References
PubMed ID Title Journal Year
12036956 Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)

Kedishvili, NY, Chumakova, OV, Chetyrkin, SV, Belyaeva, OV, Lapshina, EA, Lin, DW, Matsumura, M, Nelson, PS

J. Biol. Chem. 2002
12407145 Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE

Wu, BX, Chen, Y, Chen, Y, Fan, J, Rohrer, B, Crouch, RK, Ma, JX

Invest. Ophthalmol. Vis. Sci. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NADP-retinol dehydrogenase activity of RDH10,11 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed