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GNAT1-GDP binds to GNB1:GNGT1
Stable Identifier
R-HSA-74882
Type
Reaction [binding]
Species
Homo sapiens
Compartment
photoreceptor disc membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The phototransduction cascade (Homo sapiens)
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
GNAT1-GDP binds to GNB1:GNGT1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once transducin alpha subunit (GNAT1) is deactivated by hydrolysis of bound GTP to GDP, it reassociates with transducin beta:gamma subunits (GNB1:GNGT1) to form inactive transducin (Gt-GDP). A stoichiometric overabundance of GNB1:GNGT1 facilitates the reassociation event. The details for this event were revealed in bovine experiments (Clark et al. 2006, Fung et al. 1981).
Literature References
PubMed ID
Title
Journal
Year
6264430
Flow of information in the light-triggered cyclic nucleotide cascade of vision
Fung, BK
,
Hurley, JB
,
Stryer, L
Proc. Natl. Acad. Sci. U.S.A.
1981
16895762
Transducin subunit stoichiometry and cellular distribution in rod outer segments
Springmeyer, ML
,
Clark, CR
,
Clack, JW
,
Witzmann, FA
Cell Biol. Int.
2006
Participants
Input
GNAT1-GDP [photoreceptor disc membrane]
(Homo sapiens)
GNB1:GNGT1 [photoreceptor disc membrane]
(Homo sapiens)
Output
Gt-GDP [photoreceptor disc membrane]
(Homo sapiens)
Participates
as an event of
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
Inferred From
Gnat1-GDP binds to Gnb1:Gngt1 (Bos taurus)
Authored
Schmidt, EE (2003-07-11)
Reviewed
Makino, C (2013-04-11)
Created
Carleton, KL (2003-07-31)
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