Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Stable Identifier
R-HSA-75035
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
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DNA damage induced activation of the checkpoint kinases Chk1/Chk2(Cds1) results in the conversion and/or maintenance of CyclinB:Cdc2 complex in its Tyrosine 15 phosphorylated (inactive) state. Cdc2 activity is regulated by a balance between the phosphorylation and dephosphorylation by the Wee1/Myt1 kinase and Cdc25 phosphatase. Inactivation of the Cyclin B:Cdc2 complex likely involves both inactivation of Cdc25 and/or stimulation of Wee1/Myt1 kinase activity.
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Orthologous Events
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Bos taurus)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Caenorhabditis elegans)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Canis familiaris)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Danio rerio)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Dictyostelium discoideum)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Drosophila melanogaster)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Mus musculus)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Rattus norvegicus)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Saccharomyces cerevisiae)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Schizosaccharomyces pombe)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Sus scrofa)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Matthews, L  (2003-08-05)
Created
Matthews, L  (2003-10-31)
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