Reactome | Inactive G alpha (q) reassociates with G beta:gamma

Inactive G alpha (q) reassociates with G beta:gamma

Stable Identifier

R-HSA-750993

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Inactive G alpha (q) reassociates with G beta:gamma

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active G alpha (q) subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (q):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates.

Literature References

PubMed ID	Title	Journal	Year
15951850	The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits Siderovski, DP, Willard, FS	Int J Biol Sci	2005
16923326	Structural basis of function in heterotrimeric G proteins Oldham, WM, Hamm, HE	Q Rev Biophys	2006