Inactive G alpha (q) reassociates with G beta:gamma

Stable Identifier
R-HSA-750993
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active G alpha (q) subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (q):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates.

Literature References
PubMed ID Title Journal Year
15951850 The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

Siderovski, DP, Willard, FS

Int J Biol Sci 2005
16923326 Structural basis of function in heterotrimeric G proteins

Oldham, WM, Hamm, HE

Q Rev Biophys 2006
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