Reactome | Inactive G alpha (q) reassociates with G beta:gamma

Inactive G alpha (q) reassociates with G beta:gamma

Stable Identifier

R-HSA-750993

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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General

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SVG | | PPTX | SBGN

Inactive G alpha (q) reassociates with G beta:gamma

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The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active G alpha (q) subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (q):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates.

Literature References

PubMed ID	Title	Journal	Year
15951850	The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits Siderovski, DP, Willard, FS	Int J Biol Sci	2005
16923326	Structural basis of function in heterotrimeric G proteins Oldham, WM, Hamm, HE	Q Rev Biophys	2006