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Inactive G alpha (i) reassociates with G beta:gamma

Stable Identifier
R-HSA-751001
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active G alpha (i) subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (i):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates.

Literature References
PubMed ID Title Journal Year
15951850 The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits Int J Biol Sci 2005
16923326 Structural basis of function in heterotrimeric G proteins Q Rev Biophys 2006
Participants
Participant Of
Orthologous Events