Inactive G alpha (s) reassociates with G beta:gamma

Stable Identifier
R-HSA-751013
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active alpha subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (s):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates into the inactive heterotrimeric G-protein.

Literature References
PubMed ID Title Journal Year
14671004 Insights into G protein structure, function, and regulation

Cabrera-Vera, TM, Vanhauwe, J, Thomas, TO, Medkova, M, Preininger, A, Mazzoni, MR, Hamm, HE

Endocr Rev 2003
16923326 Structural basis of function in heterotrimeric G proteins

Oldham, WM, Hamm, HE

Q Rev Biophys 2006
15951850 The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

Siderovski, DP, Willard, FS

Int J Biol Sci 2005
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