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The Ligand:GPCR:G12/13 complex dissociates
Stable Identifier
R-HSA-751019
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)
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The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (12/13) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
Literature References
PubMed ID
Title
Journal
Year
18577758
Dissociation of heterotrimeric g proteins in cells
Lambert, NA
Sci Signal
2008
Participants
Input
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane]
(Homo sapiens)
Output
G-protein alpha (12/13):GTP [plasma membrane]
(Homo sapiens)
x 2
G-protein beta-gamma complex [plasma membrane]
(Homo sapiens)
GPCRs that activate G12/13 [plasma membrane]
(Homo sapiens)
Ligands of GPCRs that activate G12/13 [extracellular region]
Participates
as an event of
G alpha (12/13) signalling events (Homo sapiens)
Orthologous Events
The Ligand:GPCR:G12/13 complex dissociates (Bos taurus)
The Ligand:GPCR:G12/13 complex dissociates (Caenorhabditis elegans)
The Ligand:GPCR:G12/13 complex dissociates (Canis familiaris)
The Ligand:GPCR:G12/13 complex dissociates (Drosophila melanogaster)
The Ligand:GPCR:G12/13 complex dissociates (Gallus gallus)
The Ligand:GPCR:G12/13 complex dissociates (Mus musculus)
The Ligand:GPCR:G12/13 complex dissociates (Sus scrofa)
The Ligand:GPCR:G12/13 complex dissociates (Xenopus tropicalis)
Authored
Jupe, S (2010-05-18)
Reviewed
D'Eustachio, P (2010-05-22)
Created
Jupe, S (2010-05-19)
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