Reactome: A Curated Pathway Database

Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13

Stable Identifier
R-HSA-751027
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

About 25 receptors are reported to couple to the G12/13 G protein subtype (Riobo & Manning, 2005).Direct assay methods have not identified a receptor that only couples with G12. At least one receptor (5-HT4) only couples with G13, but most other receptors are reported to couple with both G12 and G13.

Literature References
Participants
Participant Of
Orthologous Events