Reactome: A Curated Pathway Database

Inactive G alpha (12/13) reassociates with G beta:gamma

Stable Identifier
R-HSA-751039
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active alpha subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (12/13):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates into the inactive heterotrimeric G-protein.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events